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Functional interplay between long non-coding RNAs and Breast CSCs
Breast cancer (BC) represents aggressive cancer affecting most women’s lives globally. Metastasis and recurrence are the two most common factors in a...
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Cancer Stem Cells (CSCs) in Tumor Ecosystem
In cancer, cancer stem cells (CSCs) is a unique cell population that could acquire the stemness ability of a stem cell that enable them to...
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Diagnostic and Prognostic Significance of Intracellular Markers of CSCs in Patients with Cancers
Intracellular markers of cancer stem cells (CSCs), e.g., ALDH1, SOX2, Oct-3/4, Bmi1, LETM1, Msi2, and Sall4 have a significant role in the isolation...
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CD44-Based Detection of CSCs: CD44 Immunodetection by Flow Cytometry
CD44 has been described in many malignancies as a marker of cancer stem cells (CSCs). Several techniques can be used to detect these cells. Here we...
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Downregulation of circ-Foxo3 in breast cancer stem-like cells
ObjectiveCancer cells having stem cell characteristics are linked to metastasis and relapse in breast cancer. Circ-Foxo3, as a circular RNA, has been...
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The transcriptional landscape of cancer stem-like cell functionality in breast cancer
BackgroundCancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients...
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In silico identification and in vitro validation of alpha-hederin as a potent inhibitor of Wnt/β-catenin signaling pathway in breast cancer stem cells
Cancer stem cells (CSCs) play a vital role in metastasis, recurrence and chemoresistance in breast cancer. β-catenin, which is a frequently over...
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Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
BackgroundCancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, progression,...
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TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
TRIM58 is a member of the TRIM protein family, which possess with E3 ubiquitin ligase activities. Studies have revealed that low expression of TRIM58...
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The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
BackgroundBreast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and...
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Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics
Metastasis of breast cancer cells involves the dissemination from primary tumor sites and migration to distant organs forming secondary tumors, which...
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Molecular Pathways in Breast Cancer Chemoresistance
Chemoresistance is one of the determinants of breast cancer (BrCA) prognosis. Chemoresistance leads to recurrence and metastasis that causes adverse...
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Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics
Metastasis of breast cancer cells involves the dissemination from primary tumor sites and migration to distant organs forming secondary tumors, which...
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Downregulation of TAB182 promotes cancer stem-like cell properties and therapeutic resistance in triple-negative breast cancer cells
TAB182 participates in DNA damage repair and radio-/chemosensitivity regulation in various tumors, but its role in tumorigenesis and therapeutic...
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Resistance to Chemotherapy in Breast Cancer
Breast cancer (BC) is the most frequently diagnosed cancer in women and the leading cause of death for women worldwide. Conventional clinical...
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Cuproptosis engages in c-Myc-mediated breast cancer stemness
BackgroundIntra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant...
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siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression
BackgroundBreast cancer, the most prevalent cancer in women worldwide, faces treatment challenges due to drug resistance, posing a serious threat to...
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Harnessing the Power of Natural Products in Overcoming Drug Resistance in Breast Cancer
This chapter explores the use of substances, including cannabis, curcumin, resveratrol, and green tea polyphenols, in the fight against drug...
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Nanomedicine Targeting Cancer Stem Cells
Cancer stem cells (CSCs) constitute a subset of cells endowed with the remarkable abilities of self-renewal, proliferation, and differentiation....
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Molecular Pathways in Breast Cancer Chemoresistance
Chemoresistance is one of the determinants of breast cancer (BrCA) prognosis. Chemoresistance leads to recurrence and metastasis that causes adverse...