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Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called...
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Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples
BackgroundSynaptophysin, chromogranin and CD56 are recommended markers to identify pulmonary tumors with neuroendocrine differentiation. Whether the...
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Lateral-Flow-Immunoassays
Im folgenden Kapitel werden Lateral-Flow-Immunoassays, von den ersten Schritten bis hin zu zukünftigen Entwicklungstrends, vorgestellt. Dabei geht es...
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Map** of Posttranscriptional tRNA Modifications by Two-Dimensional Gel Electrophoresis Mass Spectrometry
RNA modification map** by mass spectrometry (MS) is based on the use of specific ribonucleases (RNases) that generate short oligonucleotide...
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Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies
BackgroundCholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent...
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Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells
BackgroundTartrate-resistant acid phosphatase (TRAP/ ACP5 ), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in...
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A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species
BackgroundA discontinuous dose response relationship is a major characteristic of the anti-inflammatory effects of low-dose X-irradiation therapy....
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Evaluating real-time immunohistochemistry on multiple tissue samples, multiple targets and multiple antibody labeling methods
BackgroundImmunohistochemistry (IHC) is a well-established method for the analysis of protein expression in tissue specimens and constitutes one of...
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Antikörper
Der Titel des Buches „Der Experimentator – Immunologie“ lässt keinen Zweifel offen: Es dreht sich auf den folgenden Seiten grob um’s EXPERIMENTIEREN...
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Molecular characterization of adult-colonizing Streptococcus agalactiae from an area-based surveillance study in Romania
One hundred and forty-eight colonizing isolates from adult Romanian women were conventionally serotyped and screened for antibiotic resistance....
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Exercise Pre-conditioning Reduces Brain Inflammation and Protects against Toxicity Induced by Traumatic Brain Injury: Behavioral and Neurochemical Approach
Although the favorable effects of physical exercise in neurorehabilitation after traumatic brain injury (TBI) are well known, detailed pathologic and...
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Pflanzliche Lectine: Vorkommen, Eigenschaften, Analytik und Bewertung ihrer immunmodulatorischen Aktivität
Lectine gehören zur Superfamilie der Proteine, die mit Liganden Komplexe bilden. Ihre Bindungspartner sind Zuckerepitope zellulärer Glykokonjugate,...
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Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro
Focal visual cortex lesions lead to functional changes in the surrounding cortical network, possibly mediated through synaptic long-term potentiation...
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Ätherische Öle und Drogen, die ätherisches Öl enthalten
Ätherische Öle sind Stoffgemische, deren Hauptbestandteile (Mono- und Sesquiterpene) zur Naturstoffgruppe der Isoprenoide gehören (vgl. Kap. 23). Sie...
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Lewis and the Molecular Control of Development
In the early 1970’s methods were invented that revolutionized the study of individual eukaryotic genes by allowing molecular analysis of any gene of...
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Pharmaka zur Behandlung und Prophylaxe von Infektionskrankheiten
Der Begriff der Chemotherapie geht auf Paul Ehrlich zurück, der sie als eine spezifische, gegen Krankheitserreger gerichtete Therapie den...
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Screening methods for cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in non-human primates
We report here a comparison of isotopic and non-isotopic conformation analysis approach, for screening genomic DNA for coding variations in the...