Search
Search Results
-
Age- and gender-specific acute poisoning with drugs and medications affecting nervous system
BackgroundWe investigated acute poisonings resulting from medications affecting the nervous system and illicit substances at Loghman Hakim Hospital...
-
Screening Methods for the Evaluation of Antiparkinsonian Drugs
Damage to dopaminergic neurons in the substantia nigra is well-established pathophysiology of Parkinson’s Disease (PD); hence, drugs targeting...
-
Chemical constituents, pharmacological activities, and uses of common ayurvedic medicinal plants: a future source of new drugs
Natural products, especially plants and herbs, have always been a common medicament source, either as pure active principles or traditional...
-
Comparison of the Antiparkinson Activity of Levodopa, Memantine, and Guanidine-Containing Analogs of Amantadine and Memantine (IEM-2151 and IEM-2163) in Rats with Rotenone-Induced Parkinsonism
Rotenone-induced parkinsonism in rats is a widely used animal model of parkinsonism for studies of the antiparkinsonism activity of new substances....
-
Data Integration Applications in Medical Information Systems
Medical information systems play a vital role in the everyday successful treatment of patients in hospitals, general practitioners’ offices, and...
-
Recent trends of bioconjugated nanomedicines through nose-to-brain delivery for neurological disorders
The global burden of neurological disorders has been increasing day by day which calls for immediate attention to the solutions. Novel drug delivery...
-
An Insight into Herb Interactions: Clinical Evidence-Based Overview
Medicines are used for betterment of human health, and huge number of human population uses medicines for the same. But the desired effects of these...
-
-
Pharmacogenomics in Drug Metabolism Enzymes and Transporters
The safe and effective use of drug therapies play a critical role in treating disease. Interindividual variability in drug metabolism and transport...
-
Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism
Cucurbita pepo is used as a vegetable in Pakistan and its seeds are also rich in tocopherol. Data showed the pivotal role of tocopherol in the...
-
Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies
Selective monoamine oxidase B inhibitors are potential drug candidates for the treatment of Parkinson’s disease. A series of phenyl substituted...
-
Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development
Alzheimer’s disease (AD) is a priority health problem in developed countries with a high cost to society. Approximately 20% of direct costs are...
-
Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Parkinson's disease (PD) is characterized by oxidative stress and neuroinflammation as key pathological features. Emerging evidence suggests that...
-
Effect of number of medications and use of potentially inappropriate medications on frailty among early-stage older outpatients
BackgroundFrailty is an urgent concern among an aging population worldwide. However, the relationship between frailty and number and types of...
-
Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naïve patients with schizophrenia: a randomized controlled open-label study
ObjectiveDespite advances in pharmacology, the treatment of schizophrenia (SZ) remains a challenge due to relapse after antipsychotic discontinuation...
-
Implementing in vitro and in silico approaches to evaluate anti-influenza virus activity of different Bangladeshi plant extracts
Emergence of antiviral drug resistance in influenza virus remains a major public health concern worldwide. Nowadays, different herbs receive renewed...
-
Dexpramipexole Enhances K+ Currents and Inhibits Cell Excitability in the Rat Hippocampus In Vitro
Dexpramipexole (DEX) has been described as the first-in-class F1Fo ATP synthase activator able to boost mitochondrial bioenergetics and provide...
-
-
Prognostic biomarkers of Parkinson’s disease in the Spanish EPIC cohort: a multiplatform metabolomics approach
The lack of knowledge about the onset and progression of Parkinson’s disease (PD) hampers its early diagnosis and treatment. Metabolomics might shed...
