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Loss of SIL1 Affects Actin Dynamics and Leads to Abnormal Neural Migration
SIL1 is a nucleotide exchange factor for the molecular chaperone protein Bip in the endoplasmic reticulum that plays a crucial role in protein...
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Imaging and Analysis of the Dynamics of Filamentous Actin Structures in Live Endothelial Cells
The ability to view and record the movements of subcellular structures is a powerful tool that has accelerated the discovery and understanding of...
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BioID Analysis of Actin-Binding Proteins
Proteins often exist and function as part of higher-order complexes or networks. A challenge is to identify the universe of proximal and interacting...
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Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
BackgroundMetastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important...
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ERRα coordinates actin and focal adhesion dynamics
Cell migration depends on the dynamic organisation of the actin cytoskeleton and assembly and disassembly of focal adhesions (FAs). However, the...
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Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Local translation in growth cones plays a critical role in responses to extracellular stimuli, such as axon guidance cues. We previously showed that...
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper...
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The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhibit high levels of actin...
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A Ciliary Branched Actin Network Drives Photoreceptor Disc Morphogenesis
The light-detecting organelle of the photoreceptor cell is a modified primary cilium, called the outer segment. The outer segment houses hundreds of...
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Regeneration in calcareous sponge relies on ‘purse-string’ mechanism and the rearrangements of actin cytoskeleton
The crucial step in any regeneration process is epithelization, i.e. the restoration of an epithelium structural and functional integrity....
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The Coordinating Role of the Actin Cytoskeleton in Short-Term Neural Network Plasticity Involving Excitatory and Inhibitory Synapses
The problem of frequency coding is closely related to studies of the mechanisms by which inhibitory interneurons are involved in neural network...
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HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions
Cells of the innate and adaptive immune systems depend on proper actin dynamics to control cell behavior for effective immune responses. Dysregulated...
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Membrane potential dynamics of C5a-stimulated neutrophil granulocytes
Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to...
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Generation and Characterization of a Skeletal Muscle Cell-Based Model Carrying One Single Gne Allele: Implications in Actin Dynamics
UDP-N-Acetyl glucosamine-2 epimerase/N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid. Mutation...
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Human deafness-associated variants alter the dynamics of key molecules in hair cell stereocilia F-actin cores
Stereocilia protrude up to 100 µm from the apical surface of vertebrate inner ear hair cells and are packed with cross-linked filamentous actin...
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mTORC1/rpS6 and mTORC2/PKC regulate spermatogenesis through Arp3-mediated actin microfilament organization in Eriocheir sinensis
Mammalian target of rapamycin (mTOR) is a crucial signaling protein regulating a range of cellular events. Numerous studies have reported that the...
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Regulation of fenestra formation via actin-dynamin2 interaction in rat pituitary endothelial cells
Endothelial fenestrae are transcellular pores divided by a diaphragm consisting of plasmalemma vesicle-associated protein (PLVAP). They function as a...
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Neuronal Fractal Dynamics
Synapse formation is a unique biological phenomenon. The molecular biological perspective of this phenomenon is different from the fractal...
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PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial–Mesenchymal Transition
Phospholipase C Beta 1 (PLCB1) regulates the abundance of PI(4,5)P2 in the plasma membrane and is implicated in various kinds of cancers. This study...
