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ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
BackgroundAutophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in cancer progression....
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Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase
Nitidine chloride (NC) is a standard active component from the traditional Chinese medicine Zanthoxylum nitidum (Roxb.) DC. (ZN). NC has shown a...
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HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3
BackgroundHistone deacetylases (HDACs) have been shown to be involved in tumorigenesis, but their precise role and molecular mechanisms in gastric...
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Effect of punicalagin on the autophagic cell death in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease defined by the absence of estrogen receptor (ER), progesterone receptor (PR),...
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Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment
Autophagy regulates the degradation of damaged organelles and protein aggregates, and is critical for neuronal development, homeostasis, and...
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Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma
BackgroundTo investigate how Fusobacterium nucleatum ( Fn ) promotes oxidative stress and mediates proliferation and autophagy in hypopharyngeal...
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Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma
IntroductionGlioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and...
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Systems Biology and Bioinformatics Insights into the Role of Free Radical-Mediated Oxidative Damage in the Pathophysiology of Cancer
Oxidative stress plays a pivotal role in various physiological and pathological processes. The interplay between pro-oxidants and antioxidants...
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The Immunogenetics of Alopecia areata
Alopecia areata (AA) isAlopecia areata an autoimmune disease that targets the hair follicles (HF) and results in non-scarring hair loss. AA results...
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EPB41L4A-AS1 is required to maintain basal autophagy to modulates Aβ clearance
Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) plaques. Aβ is generated...
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Autophagic Control of Stem Cells Differentiation into Osteogenic Lineage—Implications in Bone Disorders
AutophagyAutophagy is a degradative metabolic process involved in sustaining the cellular homeostasis by regulating the turnover of cytosolic...
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Targeting the autophagy-miRNA axis in prostate cancer: toward novel diagnostic and therapeutic strategies
Since prostate cancer is one of the leading causes of cancer-related death, a better understanding of the molecular pathways guiding its development...
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The Role of Autophagy in the Regulation of Hematopoietic Stem Cells
Hematopoietic stem cellsHematopoietic stem cells (HSCs) reside in the bone marrow and replenish the blood cells as per the physiological requirement...
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Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease
Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently...
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The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the selective executers in the protein ubiquitination, playing a...
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Assays for Monitoring Autophagy in Stem Cells
Macroautophagy (Autophagy hereafter) mediates degradation of cytoplasmic components and organelles via the lysosome in all types of cells including...
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MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells
Chemotherapy is one of the most common therapeutic methods in advanced and metastatic tumors. Cisplatin (CDDP) is considered as one of the main...
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Exploring and exploiting the host cell autophagy during Mycobacterium tuberculosis infection
Tuberculosis, caused by Mycobacterium tuberculosis , is a fatal infectious disease that prevails to be the second leading cause of death from a single...
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The stress-responsive protein REDD1 and its pathophysiological functions
Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including...
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Hydroxychloroquine Causes Early Inner Retinal Toxicity and Affects Autophagosome–Lysosomal Pathway and Sphingolipid Metabolism in the Retina
Hydroxychloroquine (HCQ) is an anti-malarial drug but also widely used to treat autoimmune diseases like arthritis and lupus. Although there have...
