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Detection of Hypoxia in 2D and 3D Cell Culture Systems Using Genetically Encoded Fluorescent Hypoxia Sensors
In vivo oxygen availability varies widely between cellular microenvironments, depending on the tissue of origin and its cellular niche. It has long...
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Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic
This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering,...
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Strain-level profiling with picodroplet microfluidic cultivation reveals host-specific adaption of honeybee gut symbionts
BackgroundSymbiotic gut microbes have a rich genomic and metabolic pool and are closely related to hosts’ health. Traditional sequencing profiling...
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Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional...
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3D Models of Sarcomas: The Next-generation Tool for Personalized Medicine
Sarcoma is a complex and heterogeneous cancer that has been difficult to study in vitro. While two-dimensional (2D) cell cultures and mouse models...
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3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes
Due to the limited self-repair capacity of the hyaline cartilage, the repair of cartilage remains an unsolved clinical problem. Tissue engineering...
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Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration
A major clinical challenge today is the large number of bone defects caused by diseases or trauma. The development of three-dimensional (3D)...
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Functional gene-guided enrichment plus in situ microsphere cultivation enables isolation of new crucial ureolytic bacteria from the rumen of cattle
BackgroundRuminants can utilize urea as a dietary nitrogen source owing to their ability to recycle urea-N back to the rumen where numerous ureolytic...
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Proteomic-miRNA Biomics Profile Reveals 2D Cultures of Human iPSC-Derived Neural Progenitor Cells More Sensitive than 3D Spheroid System Against the Experimental Exposure to Arsenic
The iPSC-derived 3D models are considered to be a connective link between 2D culture and in vivo studies. However, the sensitivity of such 3D models...
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A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was standardized and used to...
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Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture
BackgroundThe immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences...
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Introduction to 3D Cell Culture
This chapter explains the importance of 3D cell culture and highlights its potential and benefits in comparison to traditional 2D cultivation. Since...
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Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model
PurposeRadiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges....
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Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells leading to a progressive deterioration of brain functions....
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Individual 3D-Printed Implants Made from a Copolymer of Vinylidene Fluoride with Tetrafluoroethylene: Studies of the Effects of Steam Sterilization on Structure and Toxicity
Surgical intervention for the treatment of oncological pathologies requires the use of individual implants to replace the affected tissues. This...
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Tulane Virus Persistence and Microbial Stability in 3D Food Ink under Various Storage Conditions: A Pre- and Post-Printing Analysis
3D food printers facilitate novel customization of the physicochemical properties of food. This study aimed to investigate the impact of storage...
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Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
In vitro 3D models are advanced biological tools that have been established to overcome the shortcomings of oversimplified 2D cultures and mouse...
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Biological, Natural, and Synthetic 3D Matrices
The cultivation of mammalian cells in 3D is becoming increasingly important, as it becomes clear that cells display different morphology, signaling,...
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A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy efficacy and outcome for...
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Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells
PurposeHuman induced pluripotent stem cell (hiPSC)-derived lung cell types such as alveolar epithelial cells are promising for toxicological and...
