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EPS8 variant causes deafness, autosomal recessive 102 (DFNB102) and literature review
Pathogenic variants in the EPS8 gene result in nonsyndromic hearing loss. This gene encodes the EPS8 protein in cochlear inner hair cells and...
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HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection
Microtubules (MTs) form a filamentous array that provide both structural support and a coordinated system for the movement and organization of...
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The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease
The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the...
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Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
Breast cancer metastasis is the main cause of cancer death in women, so far, no effective treatment has inhibited breast cancer metastasis....
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The regulation of junctional actin dynamics by cell adhesion receptors
The formation of cell–cell junctions and the development of stable cell–cell adhesion require the association of actin filaments with the sites of...
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Cell Junctions and the Mechanics of Hair Cell Regeneration
Hundreds of millions of people worldwide have disabling hearing loss or imbalance. A major cause of these impairments is sensory hair cell loss from...
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Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome
Down syndrome (DS) is characterized by the trisomy of chromosome 21 and by cognitive deficits that have been related to neuronal morphological...
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Differentially Expressed Erythrocyte Proteins in Neuromyelitis Optica Spectrum Disorders and Their Functional Annotation Using DAVID Bioinformatics Tool
AbstractNeuromyelitis optica spectrum disorders (NMOSD) are autoimmune disorders affecting central nervous system with immunoglobulin G positivity to...
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Actin: The Central Ubiquitous Player in the Phenomenon
Actin is a ubiquitous cytoskeletal protein and is a central player in the actin-mediated gliding motility phenomenon. In this chapter, we have...
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Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery
Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown....
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Dengue Virus Capsid-Protein Dynamics in Live Infected Cells Studied by Pair Correlation Analysis
It has become increasingly evident that unveiling the mechanisms of virus entry, assembly, and virion release is fundamental for identifying means...
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New Kids on the Block: The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction
YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth...
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Extracellular CIRP dysregulates macrophage bacterial phagocytosis in sepsis
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein...
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Genome-wide DNA methylation dynamics during epigenetic reprogramming in the porcine germline
BackgroundPrior work in mice has shown that some retrotransposed elements remain substantially methylated during DNA methylation reprogramming of...
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Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure
The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential...
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Constant ratio between the genomic components of bipartite begomoviruses during infection and transmission
The genomic components of multipartite viruses are encapsidated in separate virus particles, and the frequencies of genomic components represent one...
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Diverse functions of myosin VI in spermiogenesis
Spermiogenesis is the final stage of spermatogenesis, a differentiation process during which unpolarized spermatids undergo excessive remodeling that...
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Actin Polymerization in Apicomplexans: A Novel Perspective
In the current chapter, we summarize the major/novel findings that we had reported in the previous sections. We also provide the novel perspective...
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Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
BackgroundAcute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a poor prognosis and...
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NADPH oxidase family proteins: signaling dynamics to disease management
Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In humans, a lack of ROS causes chronic and extreme bacterial...
