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Microglial Gi-dependent dynamics regulate brain network hyperexcitability
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that G i -dependent microglial dynamics prevent neuronal...
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Rat corneal endothelial cell migration during wound repair on the basement membrane depends more on the PI-3K pathway than the cdc-42 pathway or actin stress fibers
Following a central transcorneal circular freeze injury, organ-cultured rat corneal endothelial cells surrounding the wound reorganize peripheral...
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A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics
BackgroundA20 is an anti-inflammatory molecule in nucleus pulposus (NP) cells. The anti-inflammatory properties of A20 are mainly attributed to its...
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The Effect of Simvastatin on the Dynamics of NF-κB-Regulated Neurodegenerative and Neuroprotective Processes in the Acute Phase of Ischemic Stroke
Statins are lipid-lowering drugs that act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in cholesterol...
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PTBP1 plays an important role in the development of gastric cancer
BackgroundPolypyrimidine tract binding protein 1 (PTBP1) has been found to play an important role in the occurrence and development of various...
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Metaplasticity and Synaptic Tag and Capture: Differential Dynamics of Plasticity Regulation in the Hippocampus
Synaptic plasticity is a critical underlying mechanism of learning and memory. There is extensive evidence that neural activity at one point in time...
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Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics
Rho GTPase family members were identified as critical regulators of cell morphology, actin cytoskeleton organization, cell movement, and cell cycle...
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Shc and the Control of Small GTPase Dynamics in Cellular Anchorage
Specialized metazoan cells have diverse functions which require them to interact differently with the body’s matrix scaffolds. Resident tissue cells,...
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Elucidating hippocampal proteome dynamics in moderate hepatic encephalopathy rats: insights from high-resolution mass spectrometry
Hepatic encephalopathy (HE) is a debilitating neurological disorder associated with liver failure and characterized by impaired brain function....
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A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
Okadaic acid (OA), a prevalent marine biotoxin found in shellfish, is known for causing acute gastrointestinal symptoms. Despite its potential to...
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Disulfidptosis: a new form of programmed cell death
Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to...
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Advances in Understanding the Molecular Mechanisms of Neuronal Polarity
The establishment and maintenance of neuronal polarity are important for neural development and function. Abnormal neuronal polarity establishment...
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic...
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An exploratory study of cell stiffness as a mechanical label-free biomarker across multiple musculoskeletal sarcoma cells
BackgroundCancer cells are characterized by changes in cell cytoskeletal architecture and stiffness. Despite advances in understanding the molecular...
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Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1
Estrogen-related receptor (ERR), a member of the nuclear receptor superfamily, consists of three subtypes (α, β, γ) and has strong homology with...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics
Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive abnormalities in behavior, executive functions,...
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Indirect visualization of endogenous nuclear actin by correlative light and electron microscopy (CLEM) using an actin-directed chromobody
Actin fulfills important cytoplasmic but also nuclear functions in eukaryotic cells. In the nucleus, actin modulates gene expression and chromatin...
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Two-Photon FRET/FLIM Imaging of Cerebral Neurons
Two-photon FRET (Förster resonance energy transfer) and FLIM (fluorescence lifetime imaging microscopy) enable the detection of FRET changes of...