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Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
BackgroundRisk of recurrence and progression of ductal carcinoma in situ (DCIS) to invasive cancer remains uncertain, emphasizing the need for...
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Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature
Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and...
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Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1
Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise...
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TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation
ObjectiveThe blood–brain barrier (BBB) plays a critical role in central nervous system homeostasis, and the integrity of BBB is disrupted in many...
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Primary intradural extramedullary spinal Burkitt’s lymphoma mimicking a nerve sheath tumor: a case report
Spinal involvement in lymphomas is often associated with advanced disease. Primary spinal non-Hodgkin’s lymphoma is a rare entity. A 47-year-old male...
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Real-World Evidence of the Top 100 Prescribed Drugs in the USA and Their Potential for Drug Interactions with Nirmatrelvir; Ritonavir
Nirmatrelvir (coadministered with ritonavir as PAXLOVID TM ) reduces the risk of COVID-19-related hospitalizations and all-cause death in individuals...
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The pivotal role of micro-environmental cells in a human blood–brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis
BackgroundThe blood–brain barrier (BBB) is altered in several diseases of the central nervous system. For example, the breakdown of the BBB during...
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CRISPR-Cas9 Gene Editing to Generate Isoform-Specific LAMP-2A Knockout in Human Cancer Cells
Chaperone-mediated autophagy (CMA) is a highly specific lysosomal-dependent protein degradation pathway. A critical molecular component of CMA is the...
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Use of Cocultures to Measure the Blood–Brain Barrier Permeability of Oxytocin
Primary monkey brain capillary endothelial cell cultures, with rat pericytes and astrocytes, provide an assay system for predicting the ability of...
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TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence...
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Differentiation Potential of Cancer Stem Cells In Vitro
Cancer stem cells play an indispensable role in the development and progression of cancer forming the tumor microenvironment. This microenvironment...
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Adverse drug reactions of Rituximab in patients suffering from autoimmune neurological diseases
BackgroundRituximab, a chimeric human/mouse monoclonal antibody targeting CD-20 antigens, has been used recently for various rheumatological and...
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The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
BackgroundVulvar squamous cell carcinoma (VSCC) is a rare disease with a poor prognosis. To date, there’s no proper in vitro modeling system for VSCC...
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Air–Liquid Interface Culture Model to Study Lung Cancer-Associated Cellular and Molecular Changes
Airway epithelial cells arrayed in the inner lining of the airways of the lung are believed to be the major source for the development of malignancy...
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Extracellular vesicles through the blood–brain barrier: a review
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the...
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Serum-Free Production of Human Stem Cell-Derived Liver Spheres for Cancer Metastasis Research
Renewable and scalable human liver tissue platforms are a powerful tool to study organ physiology and model diseases, such as cancer. Stem...
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Endocrine Toxicities Related to Immunotherapy
Understanding of the mechanisms by which cancer cells evade T-cell immunity through interaction with a number of ligands has led to the introduction...
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Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Chronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein that controls myriad cellular...
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Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade
BackgroundTumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by...
