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Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia
Even if treatment options for Chronic Lymphocytic Leukemia (CLL) patients have changed dramatically in the past few years, with the approval of...
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Effects of Low-Doses of Bacillus Spp. from Permafrost on Differentiation of Bone Marrow Cells
The effects of a new microorganism species ( Bacillus spp. , strain M3) isolated from permafrost specimens from Central Yakutia (Mamontova Mountain) on...
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Umbilical Cord Blood for Autologous Transfusion in the Early Postnatal Ontogeny: Analysis of Cell Composition and Viability during Long-Term Culturing
Changes in cell composition and viability as well as the content and functional activity of hemopoietic progenitor cells were analyzed during...
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Target fluorescence in-situ hybridization (Target FISH) for plasma cell enrichment in myeloma
BackgroundCytogenetic abnormalities are important prognostic markers in plasma cell myeloma (PCM) and detection is routinely performed by interphase...
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Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa
BackgroundGene expression profiles of intestinal mucosa of chickens and pigs fed over long-term periods (days/weeks) with a diet rich in rye and a...
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Role of PI3K, MAPK/ERK1/2, and p38 in Implementation of the Proliferative and Differentiation Potential of Erythroid Progenitors after Blood Loss
The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss...
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Biotechnology, In Vitro Production of Natural Bioactive Compounds, Herbal Preparation, and Disease Management (Treatment and Prevention)
Biotechnology uses living systems to develop products and plant biotechnology generates useful products or services, e.g., different bioactive...
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Hemopoietic Stimulatory Factors
Hemopoietic stimulatory growth factors encompass a series of soluble glycoproteins produced by cellular and stromal components of bone marrow...
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Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication
BackgroundClozapine is a second generation antipsychotic used to treat resistant schizophrenia and other psychotic illnesses. Leucopenia or...
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Structure and toxicity of clozapine and olanzapine on agranulocytosis
The structure and toxicity relationship of the dibenzo-1,4-diazepine derivatives has been investigated using quantum chemical calculations at the...
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Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions
PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity...
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Role of NF-κB/IKK-Dependent Signaling in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine
We studied the role of NF-κB/IKK-mediated signaling in the stimulation of growth potential of mesenchymal progenitor cells by alkaloid songorine in...
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Role of NF-κB-Dependent Signaling and p38 MAPK Signaling Pathway in the Control of Hemopoiesis during Cytostatic Administration
The study examines the role of signal pathways in triggering the compensatory reactions in the blood system in response to the cytostatic...
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Endogenous Progenitors as the Source of Cell Material for Ischemic Damage Repair in Experimental Myocardial Infarction under Conditions of Changed Concentration of Vascular Endothelial Growth Factor
We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of...
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Downregulation of SATB1 increases the invasiveness of Jurkat cell via activation of the WNT/β-catenin signaling pathway in vitro
Special AT-rich sequence-binding protein-1 (SATB1) is critical for genome organizer that reprograms chromatin organization and transcription...
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Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro
Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity...