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Role of PI3K, MAPK/ERK1/2, and p38 in Implementation of the Proliferative and Differentiation Potential of Erythroid Progenitors after Blood Loss

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Bulletin of Experimental Biology and Medicine Aims and scope

The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss (30% of circulating volume) was studied. We demonstrated the important role of PI3K and p38 in the suppression of differentiation of erythroid precursors the contribution of p38 to stimulation of mitotic activity of erythroid CFU, which maintains the growth potential of the precursors at the optimal physiological level. The classical MAPK/ERK-kinase pathway does not determine the proliferative and differentiation status of erythroid CFU.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, G. N. Zyuz’kov, E. V. Simanina, E. Yu. Sherstoboev, A. V. Chaikovskii, L. A. Stavrova, Ya. V. Burmina, T. Yu. Khrichkova, D. V. Reichart & V. E. Goldberg

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  1. A. M. Dygai
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  2. V. V. Zhdanov
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  3. L. A. Miroshnichenko
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  4. E. V. Udut
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  5. G. N. Zyuz’kov
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  6. E. V. Simanina
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  7. E. Yu. Sherstoboev
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  8. A. V. Chaikovskii
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  9. L. A. Stavrova
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  10. Ya. V. Burmina
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  11. T. Yu. Khrichkova
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  12. D. V. Reichart
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  13. V. E. Goldberg
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Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 413-416, October, 2014

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Dygai, A.M., Zhdanov, V.V., Miroshnichenko, L.A. et al. Role of PI3K, MAPK/ERK1/2, and p38 in Implementation of the Proliferative and Differentiation Potential of Erythroid Progenitors after Blood Loss. Bull Exp Biol Med 158, 417–420 (2015). https://doi.org/10.1007/s10517-015-2775-2

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  • DOI: https://doi.org/10.1007/s10517-015-2775-2

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