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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer...
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Pathological angiogenesis: mechanisms and therapeutic strategies
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-existing ones, is an essential process for growth and...
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Development of double-positive thymocytes at single-cell resolution
BackgroundT cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our...
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Genetic Studies of Natural Glycosphingolipid Ligands for NKT Cells
Glycosphingolipids (GSL) are natural ligands of NKT cells. Several laboratories have reported the in vitro activity of isoglobotriosylceramide (iGb3)...
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Intra-bone Bone Marrow Transplantation in Pig-to-Nonhuman Primates for the Induction of Tolerance Across Xenogeneic Barriers
Mixed chimerism and thymic tissue transplantation strategies have achieved xenogeneic tolerance in pig-to-mouse models, and both have been extended...
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Disassembling and Reaggregating the Thymus: The Pros and Cons of Current Assays
This review briefly describes the last decades of experimental work on the thymus. Given the histological complexity of this organ, the multiple...
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Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice
BackgroundSchistosomes are trematode worms that dwell in their definitive host’s blood vessels, where females lay eggs that need to be discharged...
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Donor Recipient Chimeric Cells Induce Chimerism and Extend Survival of Vascularized Composite Allografts
This study evaluated the efficacy of donor recipient chimeric cell (DRCC) therapy created by fusion of donor and recipient derived bone marrow cells...
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Signaling pathways in colorectal cancer: implications for the target therapies
Colorectal carcinoma (CRC) stands as a pressing global health issue, marked by the unbridled proliferation of immature cells influenced by...
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Molecular and cellular characterization of European sea bass CD3ε+ T lymphocytes and their modulation by microalgal feed supplementation
The CD3 coreceptor is a master T cell surface marker, and genes encoding CD3 ζ , γδ, and ε chains have been reported in several teleost fish. Here, a...
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Skin-on-Chip
In the last few decades, skin bioengineering has undergone several advancements. The need, understanding, and importance of develo** artificial...
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Chromosomal abnormalities and copy number variations in fetal ventricular septal defects
BackgroundThis study aimed to evaluate the applicability of chromosomal microarray analysis (CMA), rather than traditional chromosome analysis, in...
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Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease
Despite advances in immunosuppressive prophylaxis and overall supportive care, gastrointestinal (GI) graft-versus-host disease (GVHD) remains a...
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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We...
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Patients with Chromosome 11q Deletions Are Characterized by Inborn Errors of Immunity Involving both B and T Lymphocytes
Disorders of the long arm of chromosome 11 (11q) are rare and involve various chromosomal regions. Patients with 11q disorders, including Jacobsen...
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ROS and Redox Regulation/Signaling and Metabolism in Cancer Stem Cells
In this chapter entitled “ROS and Redox Regulation/Signaling and Metabolism in Cancer Stem Cells,” first the concept of “normal stem cells” and...
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Organoids in immunological research
Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and...
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Sex-Steroid Signaling in Lung Diseases and Inflammation
Sex/gender difference exists in the physiology of multiple organs. Recent epidemiological reports suggest the influence of sex-steroids in modulating...
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Role of Cyclin-Dependent Kinase Inhibitors (CKIs) as a Prognostic Biomarker for Cancer
Prognostic biomarkers have drawn significant attention in recent decades as a dependable, low-cost tool for not only early cancer diagnosis and...
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Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis
The pathogenesis of atopic dermatitis (AD) and psoriasis (Ps) overlaps, particularly the activation of the immune response and tissue damage. Here,...
