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Gene therapy: an alternative to treat Alzheimer’s disease
Alzheimer’s disease (AD), a neuro-degenerative disease that primarily affects the elderly, is a worldwide phenomenon. Loss of memory, cognitive...
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Photodynamic Therapy in Cancer
Photodynamic therapy (PDT) is recently gaining importance as an alternative to conventional clinical modalities like chemotherapy and radiation...
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FGFR4-driven plasticity in breast cancer progression and resistance to therapy
Breast cancer (BCa) is a complex and heterogeneous disease, with different intrinsic molecular subtypes that have distinct clinical outcomes and...
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Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously...
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Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulating the tumour...
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Antibody-displaying extracellular vesicles for targeted cancer therapy
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these...
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Ferroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane...
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The estimated annual financial impact of gene therapy in the United States
Gene therapy is a new class of medical treatment that alters part of a patient’s genome through the replacement, deletion, or insertion of genetic...
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Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1
PD-L1 + tumor-derived extracellular vesicles (TEVs) cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody (αPD-L1) blockade....
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FOLFOX regimen after failure of fluorouracil and leucovorin plus nanoliposomal-irinotecan therapy for advanced pancreatic cancer: a retrospective observational study
BackgroundFluorouracil, leucovorin (5FU/LV), and nanoliposomal-irinotecan (nal-IRI) combination therapy has been established as the second-line...
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Mitochondrial Transportation, Transplantation, and Subsequent Immune Response in Alzheimer’s Disease: An Update
Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterized by memory impairment and a progressive decline in cognitive...
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Therapeutic resistance to anti-oestrogen therapy in breast cancer
The hormone receptor oestrogen receptor-α (ER) orchestrates physiological mammary gland development, breast carcinogenesis and the progression of...
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Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Gene therapy is a promising approach for hereditary deafness. We recently showed that unilateral AAV1-hOTOF gene therapy with dual adeno-associated...
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Outsmarting trogocytosis to boost CAR NK/T cell therapy
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer. However, the efficacy...
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Induction Therapy and Therapeutic Antibodies
Prevention of allograft rejection is one of the crucial goals in solid organ transplantation to ensure durability of the graft and is chiefly...
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Human Embryonic Stem Cells as a Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive decline in neurocognitive performance with symptoms such as...
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Towards targeting transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have...
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Disulfidptosis: a new target for metabolic cancer therapy
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a...
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Molecular targeted therapy for anticancer treatment
Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy...
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Stereotactic body radiation therapy is beneficial for a subgroup of patients with urothelial cancer and solitary metastatic disease: a single institution real-world experience
BackgroundStandard treatment options for patients with metastatic urothelial cancer (mUC) include systemic platinum-based chemotherapy,...
