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Updates and new directions in the use of radiation therapy for the treatment of pancreatic adenocarcinoma: dose, sensitization, and novel technology
Panc reatic ductal adenocarcinoma (PDAC) is a devastating malignancy. There have been few advances that have substantially improved overall survival...
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A real-world analysis of trametinib in combination with hydroxychloroquine or CDK4/6 inhibitor as third- or later-line therapy in metastatic pancreatic adenocarcinoma
BackgroundThere are no standard third-line treatment options for metastatic pancreatic ductal adenocarcinoma (mPDAC). Trametinib in combination with...
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Tolerability of Eribulin and correlation between polymorphisms and neuropathy in an unselected population of female patients with metastatic breast cancer: results of the multicenter, single arm, phase IV PAINTER study
BackgroundMetastatic breast cancer (MBC) is an incurable disease and its treatment focuses on prolonging patients’ (pts) overall survival (OS) and...
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Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice
The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the...
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Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress
Chloroquine (CQ) and hydroxychloroquine (HCQ) are classical antimalarial drugs, and recently have been used for other applications including...
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A Phase 2 study of nivolumab in combination with modified FOLFIRINOX for metastatic pancreatic cancer
BackgroundNivolumab with modified FOLFIRINOX (mFOLFIRINOX) may have additive antitumour effects while minimising chemotherapy cytotoxicity. We...
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Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters
Microbial threats and their resistance to the available drugs are public health concerns that scientists worldwide are trying to solve. Before the...
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The lethal sex gap: COVID-19
While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the...
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Dosimetric comparison of proton therapy and CyberKnife in stereotactic body radiation therapy for liver cancers
Stereotactic body radiation therapy (SBRT) has been increasingly used for the ablation of liver tumours. CyberKnife and proton beam therapy (PBT) are...
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Immunotherapy in Melanoma and Merkel Cell Cancer
Malignant melanoma is one of the most aggressive and lethal forms of skin cancer, with incidence rates continuing to rise due to increased sun...
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In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
BackgroundMelittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy....
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Proof-of-concept study for a long-acting formulation of ivermectin injected in cattle as a complementary malaria vector control tool
BackgroundDomesticated animals play a role in maintaining residual transmission of Plasmodium parasites of humans, by offering alternative blood...
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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment
BackgroundVaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success...
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Immune correlates of protection following Rift Valley fever virus vaccination
Rift Valley fever virus (RVFV) is a hemorrhagic fever virus with the potential for significant economic and public health impact. Vaccination with an...
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The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model
Dengue virus (DENV) is the most common mosquito-borne viral disease. The World Health Organization estimates that 400 million new cases of dengue...
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Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen
Seasonal influenza vaccines must be updated annually and suboptimally protect against strains mismatched to the selected vaccine strains. We...
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Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation
Coxsackievirus B1 (CVB1) is a leading causative agent of severe infectious diseases in humans and has been reported to be associated with outbreaks...
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First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults
Background and ObjectiveMHV370, a dual antagonist of human Toll-like receptors (TLR) 7 and 8, suppresses cytokines and interferon-stimulated genes in...
