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1. Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD

   Chronic inflammatory and immune responses play key roles in the development and progression of chronic obstructive pulmonary disease (COPD)....

   Rui Shi, Renwen Liang, ... Weimin Yang in Apoptosis

   Article 23 April 2024
   

2. The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target

   Objectives

   Cellular NAD ⁺ declines in inflammatory states associated with increased activity of the leukocyte-expressed NADase CD38. In this study, we...

   Paulo Gil Alabarse, Patricia Oliveira, ... Ru Liu-Bryan in Inflammation Research

   Article Open access 16 March 2024
   

3. Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy

   Renal tubulointerstitial fibrosis (TIF) is considered as the final convergent pathway of diabetic nephropathy (DN) without effective therapies...

   Jia-ling Ji, Hui-min Shi, ... Ai-qing Zhang in Acta Pharmacologica Sinica

   Article 18 August 2023
   

4. Revisiting the isolation and characterisation of Entamoeba histolytica lipopeptidophosphoglycan

   The parasite Entamoeba histolytica is the cause of amoebic dysentery and liver abscess in humans. On the protozoan cell surface, a variety of...

   Anna Nagode, Jorick Vanbeselaere, Michael Duchêne in Parasitology Research

   Article Open access 21 February 2024
   

5. Knock-Down of CD24 in Astrocytes Aggravates Oxyhemoglobin-Induced Hippocampal Neuron Impairment

   Subarachnoid hemorrhage (SAH), as one of the most severe hemorrhagic strokes, is closely related to neuronal damage. Neurogenesis is a promising...

   **ang-**n Chen, Tao Tao, ... Wei Li in Neurochemical Research

   Article 19 October 2021
   

6. 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype

   Rationale

   18β-glycyrrhetinic acid (18β-GA) has been reported to have anti-inflammatory and neuroprotective effects. However, the therapeutic effect of...

   Hanyue Luo, Caishi Zhang, ... Wei Yao in Psychopharmacology

   Article 12 July 2023
   

7. Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils

   Inhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However,...

   Xu Jiang, **nyue **ao, ... Xuan Zhang in Cellular & Molecular Immunology

   Article 22 September 2023
   

8. Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro

   Corilagin, a natural polyphenol compound isolated from Phyllanthus urinaria L., exerts various pharmacological effects, such as antihyperglycemic,...

   Bo He, Deyun Chen, ... Zhiqiang Shen in Journal of Natural Medicines

   Article 22 January 2022
   

9. ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation

   Hepatocellular carcinoma (HCC) is one of the most lethal tumor types worldwide. Glycosylation has shown promise in the study of tumor mechanisms and...

   Da Man, Yifan Jiang, ... Jian Wu in Journal of Translational Medicine

   Article Open access 29 June 2023
   

10. Cancer cell extravasation requires ⁱplectin-mediated delivery of MT1-MMP at invadopodia

    Background

    Invadopodia facilitate cancer cell extravasation, but the molecular mechanism whereby invadopodia-specific proteases such as MT1-MMP are...

    Olivia R. Grafinger, John J. Hayward, ... Hon S. Leong in British Journal of Cancer

    Article 05 July 2024
    

11. Localizing Proteins by Tissue Printing

    This is an interesting procedure from late Pont-Lezica. He demonstrated that it is possible to show the exact location of proteins, nucleic acids,...

    Biji T. Kurien in Western Blotting for the Non-Expert

    Chapter 2021
    

12. Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

    Background

    The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E,...

    Yaw-Wen Hsu, Fu-Fei Hsu, ... Lee-Young Chau in Journal of Biomedical Science

    Article Open access 05 January 2021
    

13. HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels

    Current evidence suggests that mild cerebrovascular changes could induce neurodegeneration and contribute to HIV-associated neurocognitive disease...

    Adhikarimayum Lakhikumar Sharma, Huaixing Wang, ... Jarin Hongpaisan in Molecular Neurobiology

    Article 04 June 2022
    

14. Evaluation of cross-reactivity to Taenia hydatigena and Echinococcus granulosus in the enzyme-linked immunoelectrotransfer blot assay for the diagnosis of porcine cysticercosis

    Background

    Taenia solium is an important zoonotic parasite that infects humans as definitive host (taeniasis) and pigs as intermediate host...

    Lucho Gomez-Puerta, Ana Vargas-Calla, ... Seth E. O’Neal in Parasites & Vectors

    Article Open access 24 January 2019
    

15. Characterization of human norovirus binding to gut-associated bacterial ligands

    Objective

    Research suggests human norovirus binding to histo-blood group antigen (HBGA)-like molecules on enteric bacteria may enhance viral...

    Erin A. Almand, Matthew D. Moore, Lee-Ann Jaykus in BMC Research Notes

    Article Open access 23 September 2019
    

16. O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

    Background

    Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O -GlcNAc transferase (OGT)...

    Aishwarya Gondane, Samuel Girmay, ... Harri M. Itkonen in Journal of Biomedical Science

    Article Open access 14 February 2022
    

17. A CD22–Shp1 phosphatase axis controls integrin β₇ display and B cell function in mucosal immunity

    The integrin α ₄ β ₇ selectively regulates lymphocyte trafficking and adhesion in the gut and gut-associated lymphoid tissue (GALT). Here, we describe...

    Romain Ballet, Martin Brennan, ... Eugene C. Butcher in Nature Immunology

    Article 15 February 2021
    

18. sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis

    Soluble interleukin 1 receptor-like 1 (sST2) is a novel predictor of poor outcomes, which is involved in inflammatory response and fibrosis of...

    Jiajia Tan, **g Wei, Hongxiang Lu in Inflammation

    Article Open access 10 April 2023
    

19. The biology of SCUBE

    The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins...

    Yuh-Charn Lin, Binay K. Sahoo, ... Ruey-Bing Yang in Journal of Biomedical Science

    Article Open access 26 May 2023
    

20. Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome

    Background

    It is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier...

    Guanqiao Liu, Wen Shu, ... Bin Yu in Journal of Neuroinflammation

    Article Open access 29 April 2024