Search
Search Results
-
Impaired antibody responses were observed in patients with type 2 diabetes mellitus after receiving the inactivated COVID-19 vaccines
BackgroundPatients with type 2 diabetes mellitus (T2DM) have been reported to be more susceptible to 2019 novel coronavirus (2019-nCoV) and more...
-
Analysis of Antibody Reactivity to Malaria Antigens by Microsphere-Based Multiplex Immunoassay
Protein multiplex assays enable serological analysis of multiple target proteins simultaneously, using relatively small volumes of patient sample per...
-
Screening for Antibody Specificity and Sensitivity with ELISA
Monoclonal antibodies (MAbs) can be used to detect and quantify protein biomarker antigens (Ag). Systematic screening with an enzyme-linked...
-
Epigenetically upregulating TROP2 and SLFN11 enhances therapeutic efficacy of TROP2 antibody drug conjugate sacitizumab govitecan
TROP2 antibody drug conjugates (ADCs) are under active development. We seek to determine whether we can enhance activity of TROP2 ADCs by increasing...
-
Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys
PurposeNeutralizing antibodies, administrated through intravenous infusion, have shown to be highly efficacious in treating mild and moderate...
-
Optimizing Solid Tumor Treatment with Antibody–drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class
IntroductionAntibody–drug conjugates (ADCs) show significant clinical efficacy in the treatment of solid tumors, but a major limitation to their...
-
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
BackgroundIn Alzheimer’s disease (AD), amyloid-β 1–42 (Aβ42) neurotoxicity stems mostly from its soluble oligomeric aggregates. Studies of such...
-
Development of a 5-HT7 receptor antibody for the rat: the good, the bad, and the ugly
Our laboratory has a vested interest in measuring the location and expression of the 5-hydroxytryptamine (5-HT, serotonin) 7 (5-HT 7 ) receptor in the...
-
Antibody-Based Affinity Capture Combined with LC-MS Analysis for Identification of COVID-19 Disease Serum Biomarkers
Blood serum or plasma proteins are potentially useful in COVID-19 research as biomarkers for risk prediction, diagnosis, stratification, and...
-
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other...
-
Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial
Updated immunization strategies are needed to address multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Here we report...
-
Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
-
Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques
Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema,...
-
Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery
ObjectiveThe therapeutic options for severe asthma are limited, and the biological therapies are all parenterally administered. The purpose of this...
-
Computational Modeling of Antibody and T-Cell Receptor (CDR3 Loops)
Antibodies and T-cell receptors have been a subject of much interest due to their central role in the immune system and their potential applications...
-
Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy
A cell-based assay was developed to detect neutralizing anti-drug antibodies (NAbs) against odronextamab, a CD20xCD3 bispecific monoclonal antibody...
-
Binding Stability of Antibody—α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies
Spreading of alpha-synuclein (αSyn) may play an important role in Parkinson’s disease and related synucleinopathies. Passive immunization with...
-
Identification of unique DNA methylation sites in Kabuki syndrome using whole genome bisulfite sequencing and targeted hybridization capture followed by enzymatic methylation sequencing
BackgroundKabuki syndrome (KS) is a congenital malformation syndrome caused by mutations in the KMT2D and KDM6A genes that encode histone...
-
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
BackgroundAmyloid-β 42 (Aβ 42 ) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are...
-
Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease
BackgroundThis review describes the research and development process of gantenerumab, a fully human anti-amyloid monoclonal antibody in development...
