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IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus
BackgroundThe dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both...
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Proper and common names in the semantic system
Proper names are an important part of language and communication. They are thought to have a special status due to their neuropsychological and...
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Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis
Primary angle-closure glaucoma (PACG) is a sight-threatening eye condition that leads to irreversible blindness. While past neuroimaging research has...
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Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging
The cerebellum is recognized as being important for optimal behavioral performance across task domains, including motor function, cognition, and...
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The anterior thalamic nuclei: core components of a tripartite episodic memory system
Standard models of episodic memory focus on hippocampal–parahippocampal interactions, with the neocortex supplying sensory information and providing...
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New Aspects of VEGF, GABA, and Glutamate Signaling in the Neocortex of Human Temporal Lobe Pharmacoresistant Epilepsy Revealed by RT-qPCR Arrays
In the epilepsy spectrum, temporal lobe epilepsy (TLE) is the most common and devastating focal and symptomatic epilepsy form in adults, where more...
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APOE effects on regional tau in preclinical Alzheimer’s disease
BackgroundAPOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are...
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Brain-behavior investigation of potential cognitive markers of Alzheimer’s disease in middle age: a multi-modal imaging study
Early detection of Alzheimer’s disease remains a challenge, and the development and validation of novel cognitive markers of Alzheimer’s disease is...
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Evolving characterization of the human hyperdirect pathway
The hyperdirect pathway (HDP) represents the main glutamatergic input to the subthalamic nucleus (STN), through which the motor and prefrontal...
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Trust-based health decision-making recruits the neural interoceptive saliency network which relates to temporal trajectories of Hemoglobin A1C in Diabetes Type 1
Experimental approaches in neuroeconomics generally involve monetary utility. Utility in the health domain is relevant in diabetes because constant...
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Human Intracranial Cognitive Neurophysiology
The neurophysiological mechanisms that enable cognitive functions are typically studied noninvasively in humans using scalp magnetic resonance...
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The prefrontal cortex of the bottlenose dolphin (Tursiops truncatus Montagu, 1821): a tractography study and comparison with the human
Cetaceans are well known for their remarkable cognitive abilities including self-recognition, sound imitation and decision making. In other mammals,...
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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms...
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Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
The cingulate gyrus, as a prominent part of the human limbic lobe, is involved in the integration and regulation of complex emotional, executive,...
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Getting to Know Ourselves Through Recognizing Ourselves in Others: Neuroanatomy of Empathy in a Social Neuroscientific Model
This chapter revisits the intricate notion of ‘human beingHuman being’ elaborated by Duns Scotus to argue that empathyEmpathy is a broad...
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A revision of the dorsal origin of the frontal aslant tract (FAT) in the superior frontal gyrus: a DWI-tractographic study
The frontal aslant tract (FAT) is a white matter tract connecting the superior frontal gyrus (SFG) to the inferior frontal gyrus (IFG). Its dorsal...
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Neurons as will and representation
Memory recollections and voluntary actions are often perceived as spontaneously generated irrespective of external stimuli. Although products of our...
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The impact of aging on human brain network target controllability
Understanding how few distributed areas can steer large-scale brain activity is a fundamental question that has practical implications, which range...
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Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study
BackgroundMetabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5...
