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The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats
Synthetic organic insecticides such as pyrethroids, organophosphates, neonicotinoids, and others have the potential to disrupt ecosystems and are...
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Metabolic Approaches to the Treatment of Autism Spectrum Disorders
Children with autism spectrum disorder (ASD) may exhibit metabolic abnormalities, either with or without an underlying inherited metabolic...
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Therapeutic potential of NOX inhibitors in neuropsychiatric disorders
RationaleNeuropsychiatric disorders encompass a broad category of medical conditions that include both neurology as well as psychiatry such as major...
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An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury
Traumatic brain injury (TBI) has become a leading cause of death and disability all over the world. Pharmacological suppression of nicotinamide...
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The Link between Circadian Rhythm and ROS-Induced Cancer
Cancer is one of the leading diseases worldwide and available data has confirmed that various factors like smoking, exposure to UV radiation,...
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A New Strategy for Targeting UCP2 to Modulate Glycolytic Reprogramming as a Treatment for Sepsis A New Strategy for Targeting UCP2
Sepsis is a severe and life-threatening disease caused by infection, characterized by a dysregulated immune response. Unfortunately, effective...
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The Link Between Circadian Rhythm and ROS-Induced Cancer
Cancer is one of the leading diseases worldwide and available data has confirmed that various factors like smoking, exposure to UV radiation,...
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Role of Renin-Angiotensin System in the Pathogenesis and Progression of Non-alcoholic Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases and is increasing simultaneously with obesity and Type 2...
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Metabolic Dysregulation and Sperm Motility in Male Infertility
Nowadays, about 14% of couples have difficulty in conceiving, and half of the cases are attributed to men. Asthenozoospermia or poor sperm motility...
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Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
Senescence compromises the essential role that the endothelium plays in maintaining vascular homeostasis, so promoting endothelial dysfunction and...
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Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to severe neurological sequelae with increased morbidity and...
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Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons
BackgroundNicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species...
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Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice
Smoking is a well-established risk factor for various pathologies, including pulmonary diseases, cardiovascular disorders, and cancers. The toxic...
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Spinocerebellar Ataxia Type 7: From Mechanistic Pathways to Therapeutic Opportunities
Spinocerebellar ataxiaSpinocerebellar ataxia (SCA) type 7 (SCA7) is a cerebellar and retinal neurodegenerative diseaseNeurodegenerative diseases...
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Renin Angiotensin System in Aging and Regeneration
Age is an independent risk factor for develo** various diseases related to the cardiovascular system, kidney, nervous system, diabetesDiabetes etc....
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NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer’s Disease
Oxidative stress is involved in the pathogenesis of Alzheimer’s disease (AD), which is linked to reactive oxygen species (ROS), lipid peroxidation,...
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Bile Acid Toxicity and Protein Kinases
If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in...