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Renin Angiotensin System in Aging and Regeneration

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The Renin Angiotensin System in Cardiovascular Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 24))

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Abstract

Age is an independent risk factor for develo** various diseases related to the cardiovascular system, kidney, nervous system, diabetes etc. Renin Angiotensin System (RAS) is the main regulator of normal physiology, body fluid homeostasis, normal organ development and cardiovascular functions. Blockage in the RAS system has been shown to induce longevity and to prevent the age-related reduction in the multiple organ functions. RAS has deleterious effects in the acceleration of age-related phenotypes through the over activation of Angiotensin-II receptor type 1 (ATR-1). This promotes excessive cellular growth, inflammation and oxidative damage which leads to ageing. Other pathway is anti-inflammatory and counter-regulatory, which involves Angiotensin-II receptor type 2/Angiotensin converting enzyme/Angiotensin 1-7/Mas receptor or ATR2/ACE2/Ang1-7/MasR axis. This chapter focuses on the mechanisms of involvement of RAS in age-related diseases and the therapeutic strategies from an interdisciplinary clinical perspective.

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Authors and Affiliations

  1. Department of Translational and Regenerative Medicine, PGIMER, Chandigarh, India

    Neha Rawal & Anupam Mittal

  2. Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India

    Madhu Khullar

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  1. Neha Rawal
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  2. Anupam Mittal
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  3. Madhu Khullar
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Correspondence to Anupam Mittal or Madhu Khullar .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Manitoba, MB, Canada

    Naranjan S. Dhalla

  2. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB, Canada

    Sukhwinder K. Bhullar

  3. California State University Los Angeles, Los Angeles, CA, USA

    Anureet K. Shah

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Rawal, N., Mittal, A., Khullar, M. (2023). Renin Angiotensin System in Aging and Regeneration. In: Dhalla, N.S., Bhullar, S.K., Shah, A.K. (eds) The Renin Angiotensin System in Cardiovascular Disease. Advances in Biochemistry in Health and Disease, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-031-14952-8_17

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