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Synbiotics for the Prevention and Treatment of Skin Disorders
A profound symbiotic relationship exists between the skin and its microbial inhabitants, integral for human survival. Perturbations in this delicate...
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Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism
BackgroundPancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with an aggressive metastatic phenotype and very poor clinical prognosis....
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In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules
PurposeThis study investigates in silico the contribution of the hair follicle to the overall dermal permeability of small molecules, as published...
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Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient
BackgroundPersistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural...
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Sex-disease dimorphism underpins enhanced motion sickness susceptibility in primary adrenal insufficiency: a cross-sectional observational study
Environmental motion can induce physiological stress and trigger motion sickness. In these situations, lower-than-normal levels of...
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Studying Angiogenesis Using Matrigel In Vitro and In Vivo
Angiogenesis plays a critical role in physiology and pathophysiology of the human body; hence, it is important to explore the methods to study...
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Interrogating the Impact of Protease Activity on Tumor Progression Using 3D Spheroid Models
Cancers have a complex relationship with the surrounding environment that regulates everything from progression to response to treatment. Cell–cell...
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Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
PurposeTo elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the...
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Chronic restraint stress–induced depression-like behavior is mediated by upregulation of melanopsin expression in C57BL/6 mice retina
BackgroundDepression is associated with circadian disturbances in which melanopsin was a key mechanism. Further studies have demonstrated that...
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Animal Component-Free Medium for Long-Term Maintenance of Human Skin Explants and Its Application in Toxicity Studies of Cosmetics
Develo** skin models for dermatological and cosmetic toxicity studies is a relatively challenging area of research, considering the limitations of...
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A Systematic Review and Meta-Analysis of Social Cognition Among People Living with HIV: Implications for Non-Social Cognition and Social Everyday Functioning
Social cognition—the complex mental ability to perceive social stimuli and negotiate the social environment—has emerged as an important cognitive...
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Home-Based Infusion of Alglucosidase Alfa Can Safely be Implemented in Adults with Late-Onset Pompe Disease: Lessons Learned from 18,380 Infusions
BackgroundEnzyme replacement therapy (ERT) with alglucosidase alfa is the treatment for patients with Pompe disease, a hereditary metabolic myopathy....
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Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism
AbstractSARS-CoV-2 has evolved to enter the host via the ACE2 receptor which is part of the kinin-kallikrein pathway. This complex pathway is only...
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Monitoring Angiotropic Extravascular Migratory Metastasis In Vitro
The mechanism of cancer cell migration from the primary tumor toward secondary sites is not fully understood. In addition to intravascular cellular...
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Structure Based Machine Learning Prediction of Retention Times for LC Method Development of Pharmaceuticals
PurposeSignificant resources are spent on develo** robust liquid chromatography (LC) methods with optimum conditions for all project in the...
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API and Polymer Selection: Formulation and Process Variables
Successful 3D printability depends on various critical parameters. During formulation, ensuring the stability of the active pharmaceutical ingredient...
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Potentiation of Otoprotective Effect of Hydrocortisone Immobilized on Povidone Nanoparticles under Conditions of Intravenous Injection
The otoprotective effect of immobilized hydrocortisone was studied on the model of acute acoustic injury to the auditory analyzer in male Wistar...
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Blood Cortisol as a Biomarker in Intensive Care Unit
Despite some issues are limiting the use of blood cortisol as an excellent biomarker in intensive care units, it is seen in literature that blood...
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A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials
BackgroundPerinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth....
