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Decreased expression of miR-29 family associated with autoimmune myasthenia gravis
BackgroundMyasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the...
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In Vitro Analysis of Thymocyte Signaling
When a develo** thymocyte expresses a TCR, it is subjected to numerous interactions with self-peptide/MHC complexes that determine its fate. These...
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Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis
BackgroundIntestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also...
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Physiological and immunological barriers in the lung
The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure...
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Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis
BackgroundIntestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also...
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SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in...
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Livin promotes Th2-type immune response in airway allergic diseases
ObjectivesTo investigate the effects of livin on the Th2 immune response in airway allergic diseases (AAD) and explore the interaction among livin,...
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Identification and Purification of Human T Cell Precursors
During their development, human T cells undergo similar genomic changes and pass through the same developmental checkpoints as develo** thymocytes...
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The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state
The T cell repertoire of healthy mice and humans harbors self-reactive CD4 + conventional T (T conv ) cells capable of inducing autoimmunity. Using T...
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Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived mesenchymal stromal cells (MSCs) have been most frequently...
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Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate...
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Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
BackgroundSorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in...
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Ring Chromosome 4
We describe the cytogenomic and clinical characteristics of 47 individuals of ring chromosome 4 (RC4) published in the literature. In nine cases,...
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Gut-Skin Axis: Role in Health and Disease
The human microbiome includes microorganisms and their cumulative genetic details that reside in the human body. Skin, the body’s most external organ...
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Vascularized Islet Transplantation as Composite Islet-Kidney Grafts with Nanoparticle-Labeled Islets in Large Animal Preclinical Transplant Models
Although there are many patients with diabetes and end-stage renal failure (DM/ESRD) who would benefit from a transplantation strategy that addresses...
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Immunological imbalance in microcephalic children with congenital Zika virus syndrome
Microcephalic children due congenital Zika virus syndrome (CZS) present neurological symptoms already well described. However, several other...
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Chd4 choreographs self-antigen expression for central immune tolerance
Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigens in medullary...
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Isolation of Highly Viable Thymic Epithelial Cells for Use in In Vitro and In Vivo Experiments
Thymic epithelial cells (TECs) play multiple essential roles in T-cell development and the establishment of immune tolerance, but their isolation can...
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Patient-derived tumor models: a suitable tool for preclinical studies on esophageal cancer
Esophageal cancer (EC) is the tenth most common cancer worldwide and has high morbidity and mortality. Its main subtypes include esophageal squamous...
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The conne**on between sex and immune responses
There are notable sex-based differences in immune responses to pathogens and self-antigens, with female individuals exhibiting increased...
