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Density of Sphingosine-1-Phosphate Receptors Is Altered in Cortical Nerve-Terminals of Insulin-Resistant Goto-Kakizaki Rats and Diet-Induced Obese Mice
Sphingosine-1-phosphate (S1P) is a phosphosphingolipid with pleiotropic biological functions. S1P acts as an intracellular second messenger, as well...
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Sphingosine 1-Phosphate Metabolism and Signaling
Sphingosine 1-phosphate (S1P) is a well-defined bioactive lipid molecule derived from membrane sphingolipid metabolism. In the past decades, a series...
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Lipids and Secretory Vesicle Exocytosis
In recent years, the number of studies implicating lipids in the regulation of synaptic vesicle exocytosis has risen considerably. It has become...
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Formulation and Characterization of Ethosomes for Transdermal Delivery of Prinsepia Utilis Rogle Seed Oil with Ameliorative Effects against UVB-Induced Skin Damage
Prinsepia utilis seed oil (PUSO) is a natural medication obtained from Prinsepia utilis Rogle seed, which has been used for the treatment of skin...
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Hydroxychloroquine Causes Early Inner Retinal Toxicity and Affects Autophagosome–Lysosomal Pathway and Sphingolipid Metabolism in the Retina
Hydroxychloroquine (HCQ) is an anti-malarial drug but also widely used to treat autoimmune diseases like arthritis and lupus. Although there have...
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Lipid metabolism in idiopathic pulmonary fibrosis: From pathogenesis to therapy
Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease characterized by a progressive decline in lung function. The...
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Lysosome function in glomerular health and disease
The lysosome represents an important regulatory platform within numerous vesicle trafficking pathways including the endocytic, phagocytic, and...
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RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding
BackgroundCeramide metabolism is crucial in the progress of brain metastasis (BM). However, it remains unexplored whether targeting ceramide...
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Probiotics and Their Various Forms Supporting Skin Health
There is increasing evidence for a gut-skin axis and a potential influence of the skin microbiota on skin health. With this in mind, there is an...
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Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. Dysregulation of various...
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Sphingolipid Metabolism and Signaling in Endothelial Cell Functions
The endothelium, inner layer of blood vessels, constitutes a metabolically active paracrine, endocrine, and autocrine organ, able to sense the...
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How ceramides affect the development of colon cancer: from normal colon to carcinoma
The integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we...
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Recent advances in the formulation of sphingolipid anticancer therapeutics
BackgroundThe bioactive sphingolipids such as ceramide, sphingosine, and sphingosine-1-phosphate are of special interest as key regulators of...
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A quantitative proteomic approach revealed variations of salivary proteome during high altitude de-acclimatization
De-acclimatization occurs when an individual returns to sea level after long term exposure to high altitude. Reports on high altitude...
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Shedding Valuable Tears: Tear Fluid as a Promising Source of Disease Biomarkers
AbstractThe simplicity of collecting and evaluating tear fluid (TF) can potentially provide a convenient non-invasive diagnostic tool that easily...
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Melanocytes in regenerative medicine applications and disease modeling
Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the...
