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The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts cognitive deficits induced by the D1/D2 dopaminergic receptor agonist apomorphine in rats
RationaleSchizophrenia is a devastating mental disease that affects nearly 1% of the population worldwide. It is well documented that the...
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Autophagy and Tumour Chemotherapy
Chemotherapy is an important means of treating malignant tumours. The main role of chemotherapy drugs is to induce cell death. However, the apoptotic...
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Palliative Care and Endocrine Diseases
Palliative care in endocrine diseases is similar to palliative care in any other disease. The aim will be to reduce the symptoms, avoid short-term...
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Genetics of Pituitary Tumours
Pituitary tumours are relatively common in the general population. Most often they occur sporadically, with somatic mutations accounting for a...
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M2 Macrophages in the Metabolic Organs and in the Neuroendocrine System
Metabolism is a principle of the living organism. It is a complex network of enzymatic and nonenzymatic biochemical transformation processes to...
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Management of psychiatric disorders in Parkinson’s disease
Affective disorders (depression and anxiety), psychosis, impulse control disorders, and apathy are common and sometimes disabling psychiatric...
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Molecular Mechanisms of Carcinogenesis Associated with MEN1 Gene Mutation
AbstractDespite recent advances in genomics and the discovery of numerous genes involved in carcinogenesis, the mechanisms of malignant...
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CCNB1 affects cavernous sinus invasion in pituitary adenomas through the epithelial–mesenchymal transition
BackgroundTo investigate the relationship between cyclin B1 (CCNB1) gene expression and cavernous sinus invasion in pituitary adenomas.
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Replacement Hormone Therapy for Gender Dysphoria and Congenital Sexual Anomalies
What is it about sexuality that makes it such a burning matter since the dawn of mankind? Much was lost of humankind heritage because of society’s...
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Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary
Diethylstilbestrol (DES), an estrogen agonist, increases prolactin (PRL) cells through transdifferentiation of follicle-stimulating hormone (FSH) and...
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Dopaminergic Pathways in Obesity-Associated Inflammation
The overwhelming prevalence of obesity is a priority for public health compromising human lifespan and representing important economic burden...
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Prolactin is Not Associated with Disability and Clinical Forms in Patients with Multiple Sclerosis
An association between prolactinemia with disability, clinical forms, and sex of patients with multiple sclerosis (MS) remains unclear. The aim of...
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Palliative Care and Endocrine Diseases
Palliative care in endocrine diseases is similar to palliative care in any other disease. The aim will be to reduce the symptoms, avoid short-term...
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Cabergoline versus bromocriptine for the treatment of giant prolactinomas: A quantitative and systematic review
The aim of this study is to compare the efficacy of bromocriptine (BRC) versus cabergoline (CAB) in patients with giant prolactinomas. We searched...
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Overview of Genetically Determined Diseases/Multiple Endocrine Neoplasia Syndromes Predisposing to Endocrine Tumors
In this chapter, we present an overview of multiple endocrine neoplasia syndromes including their most important clinical and molecular features....
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Infundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report
Lymphocytic hypophysitis is an uncommon autoimmune disease. It may involve the adenohypophysis, neurohypophysis and pituitary stalk. It is most often...
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The role of collagen in cancer: from bench to bedside
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer...
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microRNAs expression profile related with response to preoperative radiochemotherapy in patients with locally advanced gastric cancer
BackgroundIt is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a...
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Detection of circulating tumor cells in patients with pituitary tumors
BackgroundCirculating tumor cells (CTCs) are tumor cells that have shed from a primary tumor and circulate in the peripheral blood. Recent...
