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Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Intestinal low-grade inflammation induced by a high-fat diet has been found to detonate chronic systemic inflammation, which is a hallmark of...
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Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence
BackgroundThe primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their potential for early...
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Changing trends in the development of AAV-based gene therapies: a meta-analysis of past and present therapies
Gene therapy has seen a transformation from a proof-of-concept approach to a clinical reality over the past several decades, with adeno-associated...
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Sex-biased and parental allele-specific gene regulation by KDM6A
BackgroundKDM6A is a demethylase encoded by a gene with female-biased expression due to escape from X inactivation. Its main role is to facilitate...
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Transdermal delivery for gene therapy
Gene therapy is a critical constituent of treatment approaches for genetic diseases and has gained tremendous attention. Treating and preventing...
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Gene therapy with bidridistrogene xeboparvovec for limb-girdle muscular dystrophy type 2E/R4: phase 1/2 trial results
Limb-girdle muscular dystrophy 2E/R4 is caused by mutations in the β-sarcoglycan ( SGCB ) gene, leading to SGCB deficiency and consequent muscle loss....
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Histological Assessment of Gene Therapy in the Canine DMD Model
Assessing histological changes is essential for characterizing muscle disease progression and for studying the response to therapies in Duchenne...
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Endophenotype trait domains for advancing gene discovery in autism spectrum disorder
Autism spectrum disorder (ASD) is associated with a diverse range of etiological processes, including both genetic and non-genetic causes. For a...
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Circulating tumour cell gene expression and chemosensitivity analyses: predictive accuracy for response to multidisciplinary treatment of patients with unresectable refractory recurrent rectal cancer or unresectable refractory colorectal cancer liver metastases
BackgroundPatients with unresectable recurrent rectal cancer (RRC) or colorectal cancer (CRC) with liver metastases, refractory to at least two lines...
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The effect of risperidone on behavioral reactions and gene expression of pro- and anti-inflammatory cytokines in neuropathic pain model induced by chronic constriction injury of the sciatic nerve in rat
BackgroundNeuropathic pain results from lesions or diseases affecting the somatosensory system. The management of a patient with chronic neuropathic...
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Placing human gene families into their evolutionary context
Following the draft sequence of the first human genome over 20 years ago, we have achieved unprecedented insights into the rules governing its...
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Viral Vector Upstream Processing and Clarification
The increasing number of gene therapy drugs entering the clinic targeting large population and/or large dosage diseases has forced gene therapy...
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Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout...
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PTEN inhibition enhances sensitivity of ovarian cancer cells to the poly (ADP-ribose) polymerase inhibitor by suppressing the MRE11-RAD50-NBN complex
BackgroundPoly (ADP-ribose) polymerase inhibitors (PARPis) can effectively treat ovarian cancer patients with defective homologous recombination...
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Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions
Calcitonin gene-related peptide neurotransmission was the target for recent development of monoclonal antibodies that effectively prevent attacks of...
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High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma
BackgroundAdaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC)....
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Integrated analysis of robust sex-biased gene signatures in human brain
BackgroundSexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the...
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Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach
BackgroundDNA methylation is an important mechanism in epigenetics, which can change the transcription ability of genes and is closely related to the...
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Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate...
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Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?
Epilepsy is a complex neurological disorder for which there are a large number of monogenic subtypes. Monogenic epilepsies are often severe and...
