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The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5
BackgroundThe role of microRNA (miRNA) in modulating the function of cancer stem cells through diverse signaling pathway has been evidenced. We here...
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MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey
BackgroundGastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and...
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Exploring the role of ubiquitin regulatory X domain family proteins in cancers: bioinformatics insights, mechanisms, and implications for therapy
UBXD family (UBXDF), a group of proteins containing ubiquitin regulatory X (UBX) domains, play a crucial role in the imbalance of proliferation and...
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An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma
BackgroundDiffuse large B-cell lymphoma (DLBCL) is one of the most aggressive malignant tumors. Chromobox (CBX) family plays the role of oncogenes in...
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The FOXO family of transcription factors: key molecular players in gastric cancer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third leading cause of cancer-related death with an oncological...
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Emerging roles and mechanisms of miR-206 in human disorders: a comprehensive review
As a member of the miR-1 family, miR-206 is located between IL-17 and PKHD1 genes in human. This miRNA has been shown to be involved in the...
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An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer
Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a...
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KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells
We studied the effect of KDM5 family demethylase inhibitors (JIB-04, PBIT, and KDOAM-25) on the penetration of SARS-CoV-2 pseudotyped viruses into...
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Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma
BackgroundIncreasing evidence has suggested that microRNAs (miRNAs) act as key post-transcriptional regulators in tumor progression. Previous studies...
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HDAC6: A unique HDAC family member as a cancer target
BackgroundHDAC6, a structurally and functionally distinct member of the HDAC family, is an integral part of multiple cellular functions such as cell...
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Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy
ING genes belong to family of tumor suppressor genes with regulatory functions on cell proliferation, apoptosis, and cellular senescence. These...
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Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer
BackgroundBreast cancer (BRCA) is the most common malignancy with high morbidity and mortality in women, and transcription factor (TF) is closely...
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RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p
BackgroundCircular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) is significantly down-regulated in various kinds of tumors, however, the...
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The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside
As a major component of the digestive system malignancies, tumors originating from the hepatic and biliary ducts seriously endanger public health....
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Integrative analysis of the ST6GALNAC family identifies GATA2-upregulated ST6GALNAC5 as an adverse prognostic biomarker promoting prostate cancer cell invasion
BackgroundST6GALNAC family members function as sialyltransferases and have been implicated in cancer progression. However, their aberrant expression...
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Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
Background and aim"Inflammatory bowel disease" (IBD) is a chronic, relapsing inflammatory disease of the intestinal tract that typically begins at a...
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A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke
BackgroundThe microRNA-17-92 (miR-17-92) cluster is one of the most extensively studied miRNA clusters. Abnormal expression of the cluster has been...
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ZEB family is a prognostic biomarker and correlates with anoikis and immune infiltration in kidney renal clear cell carcinoma
BackgroundZinc finger E-box binding homEeobox 1 (ZEB1) and ZEB2 are two anoikis-related transcription factors. The mRNA expressions of these two...
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PSMD8 can serve as potential biomarker and therapeutic target of the PSMD family in ovarian cancer: based on bioinformatics analysis and in vitro validation
BackgroundThe ubiquity-proteasome system is an indispensable mechanism for regulating intracellular protein degradation, thereby affecting human...
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A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
Worldwide, many lives have been lost in the recent outbreak of coronavirus disease. The pathogen responsible for this disease takes advantage of the...
