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In Vitro Model Systems to Study Human T Cell Development
Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and...
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A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kinetic proofreading model...
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Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment
Recently, considerable attention has been directed toward innate-like T cells (ITCs) and innate lymphoid cells (ILCs) owing to their indispensable...
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The emerging family of RORγt+ antigen-presenting cells
Antigen-presenting cells (APCs) are master regulators of the immune response by directly interacting with T cells to orchestrate distinct functional...
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Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile
BackgroundChromosomal aneuploidy is the most common birth defect. However, the developmental mechanism and gene expression profile of fetuses with...
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Hematopoietic Stem Cell Development in Mammalian Embryos
Hematopoietic stem cells (HSCs) are situated at the top of the adult hematopoietic hierarchy in mammals and give rise to the majority of blood cells...
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Genetic Strategies to Study T Cell Development
Genetics approaches have been instrumental to deciphering T cell development in the thymus, including gene disruption by homologous recombination and...
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Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions
The vast majority of Foxp3 + regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic...
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Fibroblasts as a source of self-antigens for central immune tolerance
Fibroblasts are one of the most common but also neglected types of stromal cells, the heterogeneity of which underlies the specific function of...
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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell...
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TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease
ObjectiveTo figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD).
MethodsPlasma TSLP levels were tested...
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The Beneficial Clinical Effects of Teriflunomide in Experimental Autoimmune Myasthenia Gravis and the Investigation of the Possible Immunological Mechanisms
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disease characterized by skeletal muscle weakness exacerbated with exercise. There is a...
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A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity
Genetic variants in cell division cycle 42 (CDC42) can manifest with dysmorphic features, autoinflammation, hemophagocytic lymphohistiocytosis, and...
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ILC Differentiation in the Thymus
The thymus provides a microenvironment conducive to the differentiation of innate lymphoid cells (ILCs), supplying IL-7 as well as Notch ligands....
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Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development
The generation of T-cells from stem cells in vitro could provide an alternative source of cells for immunotherapies. T-cell development from...
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Reproductive Toxicology
Reproductive toxicology is the study of adverse effects on male fertility and female fertility and the growth and development of the next generation....
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Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells
γδ T cells are heterogeneous lymphocytes located in various tissues. However, a systematic and comprehensive understanding of the origins of γδ T...
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A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized...
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RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2...
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Decreased expression of miR-29 family associated with autoimmune myasthenia gravis
BackgroundMyasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the...
