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Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation
PurposeThe objective of this study was to implement computational fluid dynamics (CFD) simulations and aerosol characterization experiments to...
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Correction to: Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Nonobese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
There was a mistake in the units of CL and Q, and in the parentheses of the formula for CL in the final model in Table 2. The corrected Table appears...
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In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis
BackgroundOsteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus ...
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Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022
BackgroundOur study aimed to assess the risk signals of antibiotic-associated diarrhea (AAD) caused by various antibiotics using real-world data and...
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Ceftolozane/tazobactam for Pseudomonas aeruginosa pulmonary exacerbations in cystic fibrosis adult patients: a case series
Management of cystic fibrosis (CF) patients colonized with Pseudomonas aeruginosa is challenging due to its virulence and multi-drug resistance....
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Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital
BackgroundThis study was carried out to determine the prevalence and the genetic background of extended-spectrum β-lactamase-producing Escherichia...
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Antibiotic Resistance Profile and Detection in ESKAPE Pathogens
Antibiotic resistance indicates the presence of a genetically determined resistance mechanism in bacteria to withstand or combat the lethal or...
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Preliminary reading of antibiogram by microdilution for clinical isolates in urine culture
PurposeWe evaluated a modification of automated antibiograms in urine cultures designed to facilitate the early interpretation of minimum inhibitory...
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Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital
PurposeThe aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate...
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Kee** up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes
BackgroundAntimicrobial resistance (AMR) is an intensifying threat that requires urgent mitigation to avoid a post-antibiotic era. Pseudomonas...
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Nanomedicines for the Pulmonary Delivery of Antibiotics
The pulmonary delivery of antibiotics is a pivotal approach in treating respiratory infections, enabling targeted drug administration while...
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Macrolides and Cystic Fibrosis
Macrolide antibiotics attracted interest as a potential therapy in cystic fibrosis (CF) due to remarkable similarities in pathogenic features with...
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Contemporary analysis of ETEST for antibiotic susceptibility and minimum inhibitory concentration agreement against Pseudomonas aeruginosa from patients with cystic fibrosis
ObjectivesCystic fibrosis (CF) acute pulmonary exacerbations are often caused by Pseudomonas aeruginosa , including multi-drug resistant strains....
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Antimicrobial Peptides and Proteins for Inhalation
Antimicrobial peptides and proteins (APPs) are gaining attraction as powerful agents against multidrug-resistant bacteria. The inhalation delivery of...
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Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures
PurposeStaphylococcus aureus is one of the most common pathogens causing bloodstream infection. A rapid characterisation of resistance to...
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In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides
PurposeSingle doses of gentamicin have demonstrated clinical efficacy in the treatment of urogenital gonorrhea, but lower cure rates for...
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Antibiotic Adjuvants and Their Synergistic Activity Against ESKAPE Pathogens
ESAKPE pathogens are acquiring resistance to the conventional and modern therapeutic strategies, becoming difficult to eradicate. The development of...
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Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis
BackgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency....
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Antibiotic resistance profile and molecular characterization of Staphylococcus aureus strains isolated in hospitals in Kabul, Afghanistan
The aim of this study was to investigate the molecular features and the antibiotic resistance profile of 98 clinical Staphylococcus aureus isolates...
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The effect of selective decontamination on the intestinal microbiota as measured with IS-pro: a taxonomic classification tool applicable for direct evaluation of intestinal microbiota in clinical routine
Selective decontamination of the digestive tract (SDD) is aimed at elimination of potential pathogenic microorganisms. In this study, the effect of...
