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Bioinformatic identification reveals a m6A-binding protein, IGF2BP2, as a novel tumor-promoting gene signature in thyroid carcinoma
N6-methyladenosine (m6A) modification plays a crucial role in thyroid carcinoma (THCA). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) is a...
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Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior
Uveal melanoma (UM) is the most frequent primary intraocular malignancy with high metastatic potential and poor prognosis. Macrophages represent one...
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Identification of CCL20 as a Key Biomarker of Inflammatory Responses in the Pathogenesis of Intracerebral Hemorrhage
Inflammatory responses after intracerebral hemorrhage (ICH) contribute to severe secondary brain injury, leading to poor clinical outcomes. However,...
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Machine learning framework develops neutrophil extracellular traps model for clinical outcome and immunotherapy response in lung adenocarcinoma
Neutrophil extracellular traps (NETs) are novel inflammatory cell death in neutrophils. Emerging studies demonstrated NETs contributed to cancer...
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Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
Acquisition of a lipid-laden phenotype by immune cells has been defined in infectious diseases and atherosclerosis but remains largely...
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Identification of SV2C and DENR as Key Biomarkers for Parkinson’s Disease Based on Bioinformatics, Machine Learning, and Experimental Verification
The objective of this study is to investigate the potential biomarkers and therapeutic target genes for Parkinson’s disease (PD). We analyzed four...
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Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles...
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Identification of Potential Biomarkers for Patients with DWI-Negative Ischemic Stroke
Ischemic stroke is the leading cause of long-term disability in adults, accounting for 80% of stroke cases. Diffusion weighted imaging (DWI)...
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The interplay of immunology and cachexia in infection and cancer
Diverse inflammatory diseases, infections and malignancies are associated with wasting syndromes. In many of these conditions, the standards for...
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Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood
Lung cancer accounts for more than half of the new cancers diagnosed world-wide with poor survival rates. Despite the development of chemical,...
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Impact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression
BackgroundBreast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The...
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Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway
Hepatic steatosis plays a detrimental role in the onset and progression of alcohol-associated liver disease (ALD). Mesencephalic astrocyte-derived...
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Lipid Metabolism in Tumor-Associated Fibroblasts
Tumor- or cancer-associated fibroblasts (TAFs), one of the most abundant stromal cell types in various carcinomas, consist of a heterogeneous cell...
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Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma
BackgroundThis study aimed to probe and verify aberrantly methylated and expressed genes in hepatoblastoma and to analyze their interactions with...
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SARS-CoV-2 productively infects human brain microvascular endothelial cells
BackgroundThe emergence of the novel, pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global health emergency....
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Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention, and Targeted Therapy
Skin malignancy is one of the most common cancer types in white population of world over. Occurrence of skin cancer, melanoma and non-melanoma skin...
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The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular...
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Brown adipose tissue and alzheimer’s disease
Alzheimer’s disease (AD), the most common type of senile dementia, is a chronic neurodegenerative disease characterized by cognitive dysfunction and...
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Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease
BackgroundWhile Alzheimer disease (AD) is generally considered as a brain disorder, blood biomarkers may be useful for the diagnosis and prediction...
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Trophic activities of endoplasmic reticulum proteins CDNF and MANF
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal...
