Search
Search Results
-
The Influence of Maternal Hypoxia and Buspirone during Pregnancy on Cognitive Abilities and a Stress Response in Adult Male Offspring
Spatial learning, memory, and reactivity of the hypothalamic—pituitary—adrenocortical system (HPA axis) were studied in adult male rats, whose...
-
Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats
We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and...
-
The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders
CNSCentral nervous system (CNS) diseases, including psychiatric disordersPsychiatric disorders, represent a significant opportunity for the discovery...
-
Prediction of the First-Pass Metabolism of a Drug After Oral Intake Based on Structural Parameters and Physicochemical Properties
Background and ObjectiveThe oral first-pass metabolism is a crucial factor that plays a key role in a drug’s pharmacokinetic profile. Prediction of...
-
Prenatal Stimulation of 5-HT1A Receptors Improves Adaptive Behavior in Prenatally Stressed Rats
Various types of adaptive behavior during the prepubertal period were analyzed in the offspring of rats receiving chronic injections of serotonin...
-
Exploring gender differences in pharmacokinetics of central nervous system related medicines based on a systematic review approach
Due to the inevitable differences in physiological and/or genetic factors between genders, the possibility that differences in pharmacokinetics...
-
Clary sage essential oil and its biological activities
Salvia sclarea or “clary sage” is an aromatic plant that is used for various ailments especially among the women. The aim of this investigation was...
-
Experimental Evaluation of Anxiolytic and Analgesic Properties of a New Linear Methoxyphenyltriazaalkane Derivative with Cardiotropic Activity
The anxiolytic and analgesic properties of compound ALM-802, a cardiotropic linear methoxyphenyltriazaalkane derivative, combining pharmacophore...
-
FTLD Treatment: Current Practice and Future Possibilities
While behavioral variant frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA) remain unrelenting and universally fatal conditions,...
-
Reflections on a 40-year career in drug design and discovery
In this article, I reflect on a 40-year career in drug discovery at Bristol Myers Squibb that encompassed the cardiovascular, central nervous system...
-
State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References
The Biopharmaceutics Drug Disposition Classification system (BDDCS) is a four-class approach based on water solubility and extent of...
-
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans
PurposeA dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical animal species...
-
Role of GABAA Receptors in the Mechanism of In Vivo Psychotropic Activity of Amitriptyline in Rats
Standard water-reinforced drug discrimination model was employed to train Wistar rats to discriminate the intraperitoneal injections of tricyclic...
-
Pharmacokinetics: Theory and Application in Drug Discovery and Development
Pharmacokinetics (PK) is the study of kinetics of drugs, following administration in the body, and includes the quantitative study of the...
-
Role of Benzodiazepines in Anxiety Disorders
This chapter reviews the role of benzodiazepines (BZs) in the treatment of anxiety disorders, specifically panic disorder with or without...
-
Promising biomarkers and therapeutic targets for the management of Parkinson's disease: recent advancements and contemporary research
Parkinson’s disease (PD) is one of the progressive neurological diseases which affect around 10 million population worldwide. The clinical...
-
Psychiatric illness and regression in individuals with Phelan-McDermid syndrome
BackgroundPhelan-McDermid syndrome (PMS) is a genetic condition characterized by intellectual disability, speech and language deficits, hypotonia,...
-
Current Research on Complementary and Alternative Medicine (CAM) in the Treatment of Anxiety Disorders: An Evidence-Based Review
Complementary and alternative medicine (CAM) encompasses a wide range of different nonmainstream therapies that have been increasingly used for...