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Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications
Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays of 1–6 base pair sequence motifs, that comprise a...
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Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
An essential regulatory hub for retroviral replication events, the 5’ untranslated region (UTR) encodes an ensemble of cis-acting replication...
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Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila
Innate behaviors are frequently comprised of ordered sequences of component actions that progress to satisfy essential drives. Progression is...
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Sequence determinants of human gene regulatory elements
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we...
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Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
Determining the functional role of thousands of genetic sequence variants (mutations) associated with genetic diseases is a major challenge. Here we...
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DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers
Enhancer sequences control gene expression and comprise binding sites (motifs) for different transcription factors (TFs). Despite extensive genetic...
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Sequence-dependent synergistic effect of aumolertinib-pemetrexed combined therapy on EGFR-mutant non-small-cell lung carcinoma with pre-clinical and clinical evidence
BackgroundInevitably developed resistance of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) limited...
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Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer
BackgroundThere is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy...
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DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy
BackgroundTIGIT is an immune checkpoint under investigation as therapeutic target. Understanding the regulation of TIGIT on an epigenetic level might...
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Generation of Rare Human NMDA Receptor Variants in Mice
The analysis of rare NMDAR gene variants in mice, coupled with a fundamental understanding of NMDAR function, plays a crucial role in achieving...
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Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors
BackgroundDysregulation of fibroblast growth factor receptor (FGFR ) signaling pathway has been observed in head and neck squamous cell carcinoma...
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Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity
BackgroundNon-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings...
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Functions and Clinical Significance of Myocardial Cell-Derived Immunoglobulins
Immunoglobulins (Igs) have been widely accepted to be exclusively expressed by B cells. Nonetheless, this theory is challenged by mounting evidence...
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The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment
In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent chimeric antigen receptor T...
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Scarless Baculovirus Genome Editing Using Lambda-Red Recombineering in E. coli
Baculoviruses are widely used for their potential as biological pesticide and as platform for the production of recombinant proteins and gene therapy...
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VanA-Enterococcus faecalis in Poland: hospital population clonal structure and vanA mobilome
The aim of our study was to characterize the epidemiological situation concerning nosocomial vancomycin-resistant Enterococcus faecalis of...
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Amplification of LTRs of extrachromosomal linear DNAs (ALE-seq) identifies two active Oryco LTR retrotransposons in the rice cultivar Dong**
Long terminal repeat retrotransposons (LTR-RTs) make up a considerable portion of plant genomes. New insertions of these active LTR-RTs modify gene...
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Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible,...
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Functional map** of the somatosensory cortex using noninvasive fMRI and touch in awake dogs
Dogs are increasingly used as a model for neuroscience due to their ability to undergo functional MRI fully awake and unrestrained, after extensive...
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Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies
BackgroundThe genome of SARS-CoV-2 is susceptible to mutations during viral replication due to the errors generated by RNA-dependent RNA polymerases....
