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Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
“Path to a good mood lies through the gut.” This statement seems to imply that it has long been believed that the gut is connected with the brain....
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Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Objective and designCompelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel...
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Efficacy and safety of infliximab and adalimumab in inflammatory bowel disease patients
IntroductionInflammatory bowel disease (IBD), consists of two primary types: Ulcerative Colitis (UC) and Crohn’s Disease (CD). Infliximab (IFX) and...
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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection
Since the early 1990s, when Robert’s and Szabo’s cytoprotection concept had already been more than one decade old, but still not implemented in...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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Kinin B1 receptor and TLR4 interaction in inflammatory response
ObjectiveWe aimed to broaden our understanding of a potential interaction between B1R and TLR4, considering earlier studies suggesting that...
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Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson’s disease in mice
Parkinsonism is an age-related neurodegenerative illness that affects motor coordination leading to loss of dopaminergic neurons. Many medications...
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Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain
BackgroundPrevious observational studies have indicated a complex association between gut microbiota (GM) and neuropathic pain (NP). Nonetheless, the...
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An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB
Alzheimer’s disease (AD) is a most prevalent neurologic disorder characterized by cognitive dysfunction, amyloid-β (Aβ) protein accumulation, and...
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Dissection of pro-tumoral macrophage subtypes and immunosuppressive cells participating in M2 polarization
Alternatively activated macrophage (M2) polarization can result in one of four subtypes based on cytokines and signaling pathways associated with...
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An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid
IntroductionThe efficacy of cancer treatments has links to the intestinal microbiome. Mucositis is a dose-limiting intestinal pro-inflammatory side...
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Exploring the therapeutic effects of sulforaphane: an in-depth review on endoplasmic reticulum stress modulation across different disease contexts
The endoplasmic reticulum (ER) is an intracellular organelle that contributes to the folding of proteins and calcium homeostasis. Numerous elements...
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The potential of zebrafish as drug discovery research tool in immune-mediated inflammatory disease
Immune-mediated inflammatory disease (IMID) prevalence is estimated at 3–7% for Westernised populations, with annual incidence reported at almost 1...
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Novel antiarthritic mechanisms of Azelaic acid against CFA-induced arthritis in rats by modulating pro- and anti-inflammatory cytokines network
An immunologic system attacking the body’s own tissues is a hallmark of autoimmune disorders, which encompass a wide range of unique conditions....
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Astaxanthin treatment decreases pro‐inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology: A randomized clinical trial
Research questionIn a randomized, triple-blind, placebo-controlled clinical trial (RCT), we investigated the effect of astaxanthin (AST) on...
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Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
BackgroundIn recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. Both TSLP and IgE...
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Topical diosmetin attenuates nociception and inflammation in a ultraviolet B radiation-induced sunburn model in mice
Burns are a global health problem and can be caused by several factors, including ultraviolet (UV) radiation. Exposure to UVB radiation can cause...
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NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype
BackgroundSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory...
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Comprehensive analysis of single cell and bulk RNA sequencing reveals the heterogeneity of melanoma tumor microenvironment and predicts the response of immunotherapy
BackgroundTumor microenvironment (TME) heterogeneity is an important factor affecting the treatment response of immune checkpoint inhibitors (ICI)....
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TRIM25-mediated XRCC1 ubiquitination accelerates atherosclerosis by inducing macrophage M1 polarization and programmed death
BackgroundMacrophage-mediated cleaning up of dead cells is a crucial determinant in reducing coronary artery inflammation and maintaining vascular...
