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Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies
BackgroundChildhood epilepsies are caused by heterogeneous underlying disorders where approximately 40% of the origins of epilepsy can be attributed...
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An Extended Neck Position is Likely to Produce Cervical Spine Injuries Through Buckling in Accidental Head-First Impacts During Rugby Tackling
Catastrophic cervical spine injuries in rugby often occur during tackling. The underlying mechanisms leading to these injuries remain unclear, with...
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Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2
Ribavirin ( 1 ) esters 4–36 have been synthesized and tested for their anti-inflammatory and anti-viral properties against SARS-CoV-2. The impaired...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients
In paediatric oncology, genomics raises new ethical, legal and psychological issues, as somatic and constitutional situations intersect throughout...
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Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach
Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine...
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Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth
AbstractPhysiological root resorption of deciduous teeth is a normal phenomenon occurring during the developmental stages of children. Previous...
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Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer
Germline mutations in BRCA1 and BRCA2 (g BRCA1/2 ) are required for a PARP inhibitor therapy in patients with HER2-negative (HER2−) advanced breast...
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Fluorescence Recognition of Hydrazine Driven by Neighboring Group Participation
Hydrazine (N 2 H 4 ) has toxic effects on the environment. Although a variety of reactive probes have been used to identify hydrazine, practical...
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Benzothiazole-Quinoline-Based Fluorescent Probe for Fe3+ and its Applications in Environmental and Biological Samples
Due to the its high abundance, iron ion contamination and toxicity is one of the most challenging issue for living beings. Although, iron is...
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MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting...
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Illuminating the Power of V2O5 Nanoparticles: Efficient Photocatalytic Degradation of Organic Dyes under Visible Light
This research explores the synthesis, characterization, and application of Vanadium Pentoxide nanoparticles (V 2 O 5 NPs), focusing on their efficacy in...
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ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine
Coordination complexes of cobalt represent a potential alternative to anticancer platinum-derived drugs owing to multiple activities and better...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Synthesis of Carbon Dots via Microwave-Assisted Process: Specific Sensing of Fe(III) and Antibacterial Activity
Carbon dots synthesized from a renewable and sustainable source of biomass have greater attention in the nanomaterial research field. In the present...
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First Insight into the Phylogenetic Diversity of Bovicola caprae Infesting Goats of Different Agro-climatic Locations in India
Bovicola caprae is an important obligate ectoparasite of goats worldwide including India. The present study aimed at the molecular confirmation,...
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Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. Misfolding or unfolding...
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Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach
In 1987, Won invented the solid-phase porous microsphere (MS), which stores bioactive compounds in many interconnected voids. Spherical particles...
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Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
