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Hydrogels for Musculoskeletal Tissue Engineering
The advancements in scaffold-supported cell therapy for musculoskeletal tissue engineering have been truly dramatic in the last couple of decades.... -
Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use... -
Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,... -
Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules
Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying... -
Self-Assembling Nanopeptides Become a New Type of Biomaterial
Combining physics, engineering, chemistry and biology, we can now design, synthesize and fabricate biological nano-materials at the molecular... -
Modulating Extracellular Matrix at Interfaces of Polymeric Materials
As extracellular matrices (ECM) closely interact with cells in living tissues and, through this, influence essentially any aspect of life... -
Clinical characteristics and factors associated with survival rate of patients with non-muscle invasive bladder cancer attending at a Tertiary Hospital in Somalia
BackgroundA few studies regarding the epidemiology and risk factors of Non-muscle Invasive Bladder Cancer (NMIBC) are reported from Sub-Saharan...
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EGFR mutations induce the suppression of CD8+ T cell and anti-PD-1 resistance via ERK1/2-p90RSK-TGF-β axis in non-small cell lung cancer
BackgroundNon-small cell lung cancer (NSCLC) patients with EGFR mutations exhibit an unfavorable response to immune checkpoint inhibitor (ICI)...
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Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study
BackgroundChildhood, teenage and young adult (CTYA, 0–24 years) cancers are rare and diverse, making timely diagnosis challenging. We aim to explore...
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Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study
BackgroundThis study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion...
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Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach
Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine...
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers
BackgroundThe incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified...
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Intricate effects of post-translational modifications in liver cancer: mechanisms to clinical applications
Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high...
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Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer
Germline mutations in BRCA1 and BRCA2 (g BRCA1/2 ) are required for a PARP inhibitor therapy in patients with HER2-negative (HER2−) advanced breast...
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Association of low adherence to weekly cisplatin with outcomes in patients with head and neck squamous cell carcinoma: a retrospective cohort study
BackgroundThe National Comprehensive Cancer Network (NCCN) guideline recommends consideration of weekly cisplatin as an alternative option for...
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Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination
BackgroundLarge non-apoptotic vesicles released from the plasma membrane protrusions are classified as large-EVs (LEVs). However, the triggers of LEV...
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Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas
BackgroundThe clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale,...
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Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling
BackgroundOvarian cancer patients’ resistance to first-line treatment posed a significant challenge, with approximately 70% experiencing recurrence...
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Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine
BackgroundGlaucoma is the leading cause of irreversible blindness worldwide. Normal tension glaucoma (NTG) is a distinct subtype characterized by...
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The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
BackgroundGastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations such as mutations...