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Article
Open AccessLACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer
LACTB was recently identified as a mitochondrial tumour suppressor that negatively affects cancer cell proliferation by inducing cell death and/or differentiation, depending on the cell type and tissue. Howeve...
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Article
Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth
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Article
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth
Tumors can reprogram the functions of metabolic enzymes to fuel malignant growth; however, beyond their conventional functions, key metabolic enzymes have not been found to directly govern cell mitosis. Here, ...
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Article
LACTB is a tumour suppressor that modulates lipid metabolism and cell state
Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factor...
