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  1. No Access

    Article

    Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

    The Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs) are serine/threonine-directed protein kinases that are activated following increases in intracellular calcium, playing a critical role in neuronal sig...

    Fan Wu, Kayla Hill, Qiaojun Fang, Zuhong He… in Cellular and Molecular Life Sciences (2022)

  2. Article

    Open Access

    Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function

    Inherited hearing loss is associated with gene mutations that result in sensory hair cell (HC) malfunction. HC structure is defined by the cytoskeleton, which is mainly composed of actin filaments and actin-bi...

    Qiaojun Fang, Yuhua Zhang, Peng Da, Buwei Shao, Haolai Pan, Zuhong He… in Scientific Reports (2019)

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  3. No Access

    Article

    Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

    Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn ...

    Muhammad Waqas, Shasha Zhang, Zuhong He, Mingliang Tang… in Frontiers of Medicine (2016)

  4. Article

    Open Access

    Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro

    Aminoglycosides are ototoxic to the cochlear hair cells and mitochondrial dysfunction is one of the major mechanisms behind ototoxic drug-induced hair cell death. TRMU (tRNA 5-methylaminomethyl-2-thiouridylate...

    Zuhong He, Shan Sun, Muhammad Waqas, **aoli Zhang, Fu** Qian… in Scientific Reports (2016)

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