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Open AccessA ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy
Radiation colitis is the leading cause of diarrhea and hematochezia in pelvic radiotherapy patients. This work advances the pathogenesis of radiation colitis from the perspective of ferroptosis. An oral Picker...
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Open AccessLeveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors
Overexpressed Mdm2 and its 7homolog MdmX impair p53 activity in many cancers. Small molecules mimicking a p53 peptide can effectively inhibit Mdm2 but not MdmX. Here, we show a strategy for improving lead comp...
