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Article
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been achieved. We developed an apolipoprotein...
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Article
Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex
Methyl-CpG binding protein 2 (MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA processing. Duplication of MECP2-containing genomic segments causes MECP2 duplication syn...
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Article
Open AccessMicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors
Duplication of MECP2 (Methyl-CpG-binding protein 2) causes severe mental illness called MECP2 duplication syndrome (MDS), yet the underlying mechanism remains elusive. Here we show, in Tg(MECP2) transgenic mouse ...
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Article
Effect of screw casing structure on descending of burdens in COREX shaft furnace
COREX shaft furnace (SF) is a typical screw feeder with a storage container coupled with eight screw casings and screws. The structure of screw casing plays an important role in the moving behavior of burdens,...
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Article
Open AccessElectrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex
The coexistence of electrical and chemical synapses among interneurons is essential for interneuron function in the neocortex. However, it remains largely unclear whether electrical coupling between interneuro...
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Article
Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice
The basal forebrain (BF) cholinergic neurons have long been thought to be involved in behavioral wakefulness and cortical activation. However, owing to the heterogeneity of BF neurons and poor selectivity of t...
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Article
Open AccessErratum to: Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
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Article
Open AccessReciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs
MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequentl...
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Article
Generation of macaques with sperm derived from juvenile monkey testicular xenografts
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Article
Open AccessNovel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
Young neurons in the develo** brain establish a polarized morphology for proper migration. The PIWI family of piRNA processing proteins are considered to be restrictively expressed in germline tissues and se...
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Article
Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity
Mutations in the X-linked gene encoding the transcriptional modulator methyl–CpG-binding protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type specific gene deletion in mice to...
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Article
Role of the PTEN signaling pathway in autism spectrum disorder
Autism is an etiologically heterogeneous group of neurodevelopmental disorders, diagnosed mostly by the clinical behavioral phenotypes. The concept that the tumor-related gene PTEN plays a critical role in autism...
