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    Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials

    The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

    **an-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li… in Journal of Translational Medicine (2018)

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