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  1. Article

    Open Access

    Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma

    Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy. Although its incidence is lower than that of hepatocellular carcinoma (HCC), ICC has a worse prognosis, and it is more ...

    Liye Tao, Yali Wang, Zefeng Shen, **gwei Cai, Junhao Zheng… in Hepatology International (2024)

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  2. Article

    Open Access

    UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma

    The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. The first targeted therapy, sorafenib, prolonged the overall survival by months. However, re...

    Junjie Xu, Lin Ji, Yeling Ruan, Zhe Wan… in Signal Transduction and Targeted Therapy (2021)

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  3. Article

    Open Access

    N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

    Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understand...

    Junjie Xu, Zhe Wan, Minyue Tang, Zhongjie Lin, Shi Jiang, Lin Ji… in Molecular Cancer (2020)

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  4. Article

    eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer

    Epigenetic aberrations of tumor suppressor genes (TSGs), particularly DNA methylation, are frequently involved in the pathogenesis of gastric cancer (GC). Through a methylome study, we identified eIF4EBP3 as a...

    Shuting Zhai, Shuang Lin, Zhongjie Lin, Junjie Xu, Tong Ji, Ke Chen… in Gastric Cancer (2020)

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  5. Article

    Open Access

    miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR

    HCC is a common malignancy worldwide and surgery or reginal treatments are deemed insufficient for advanced-stage disease. Sorafenib is an inhibitor of many kinases and was shown to benefit advanced HCC patien...

    Lin Ji, Zhongjie Lin, Zhe Wan, Shunjie **a, Shi Jiang, Dong Cen… in Cell Death & Disease (2020)

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  6. No Access

    Chapter and Conference Paper

    Modified Quasilinearization Method for Optimal Launch Mission Planning Problems

    Optimal launch mission planning is one of the most important engineering fields where optimization tools and optimal control theory have found routine application. Optimal control theory is critical for launch...

    Zhongjie Lin, Yongsheng Yang, Zhongliang ** in Practical Applications of Intelligent Syst… (2012)

  7. No Access

    Article

    Clinical pathological analysis of synovial sarcoma

    To investigate the clinical diagnosis and differential diagnosis of synovial sarcoma (SS).

    Ling Yang, Bogen Song, zhongjie Lin, Weiming Zhang… in Chinese Journal of Clinical Oncology (2007)