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Article
Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
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Article
Etiological subgroups of term small-for-gestational-age and childhood health outcomes
Small-for-gestational-age (SGA) has a heterogeneous etiology. Our study aimed to examine the childhood health outcomes of etiology-distinct term SGA subgroups.
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Article
Open AccessGenome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...
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Article
Open AccessComparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort
Gestational diabetes mellitus (GDM) has been associated with adverse health outcomes for mothers and offspring. Prevalence of GDM differs by country/region due to ethnicity, lifestyle and diagnostic criteria. ...
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Article
Open AccessAssisted hatching of vitrified-warmed blastocysts prior to embryo transfer does not improve pregnancy outcomes
This study aims to determine the impact of assisted hatching (AH) on pregnancy outcomes in vitrified-warmed blastocyst transfers, and evaluate if embryo expansion or morphology influences outcomes.
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Article
Retinol-binding protein 4, fetal overgrowth and fetal growth factors
Retinol-binding protein 4 (RBP-4) is an adipokine involved in regulating insulin sensitivity which would affect fetal growth. It is unclear whether RBP-4 is associated with fetal overgrowth, and unexplored whi...
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Article
Risk factors for recurrent macrosomia and child outcomes
Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in lon...
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Article
Open AccessVitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study
The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, ...
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Article
Three alternative methods to resolve paradoxical associations of exposures before term
To propose three methods to estimate associations between pregnancy exposures and outcomes before term, including the association between preeclampsia and preterm fetal-infant mortality, while avoiding the se...
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Article
Open AccessPerinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans
In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy c...
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Article
Open AccessPrevalence and risk factors of posttraumatic stress disorder among survivors five years after the “Wenchuan” earthquake in China
The aim of this study was to investigate the prevalence of posttraumatic stress disorder (PTSD) and its risk factors among survivors in a heavily-hit area five years after the Wenchuan earthquake in 2008, China.
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Article
Open AccessInfluence of health-related quality of life on health service utilization in Chinese rural-to-urban female migrant workers
Rural-to-urban migrant workers have been increasing rapidly in China over recent decades. Health related quality of life (HRQOL) may affect health service utilization. There is a lack of data on HRQOL in relat...
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Article
Open AccessAssociation between maternal comorbidity and preterm birth by severity and clinical subtype: retrospective cohort study
Preterm birth (PTB) is a major cause of infant morbidity and mortality, but the relationship between comorbidity and PTB by clinical subtype and severity of gestational age remains poorly understood. We evalua...
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Article
Open AccessThe joint influence of marital status, interpregnancy interval, and neighborhood on small for gestational age birth: a retrospective cohort study
Interpregnancy interval (IPI), marital status, and neighborhood are independently associated with birth outcomes. The joint contribution of these exposures has not been evaluated. We tested for effect modifica...
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Article
Open AccessDoes one size fit all? The case for ethnic-specific standards of fetal growth
Birth weight for gestational age is a widely-used proxy for fetal growth. Although the need for different standards for males and females is generally acknowledged, the physiologic vs pathologic nature of ethn...
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Article
Target Height as Predicted by Parental Heights in a Population-Based Study
The corrected midparental height method was introduced by Tanner in 1970 (Tanner method) and is commonly used to estimate target height in children to evaluate the effectiveness of growth-promoting therapies. ...
