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  1. Article

    Open Access

    Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops

    Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. Therefore, targeting RANKL or its signaling pathway has been ...

    **g Li, Li Zeng, Juan **e, Zhiying Yue, Huayun Deng, Xueyun Ma… in Scientific Reports (2015)

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  2. No Access

    Article

    LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

    LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mous...

    Jian Luo, Zhengfeng Yang, Yu Ma, Zhiying Yue, Hongyu Lin, Guojun Qu… in Nature Medicine (2016)

  3. Article

    Open Access

    SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

    Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and proliferative activities in cancer cells. The binding of hexokinase 2 to the outer membrane of mitochondria is critical for...

    Xun Shangguan, Jianli He, Zehua Ma, Weiwei zhang, Yiyi Ji… in Nature Communications (2021)

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  4. No Access

    Article

    Assessing the thrombosis risk of peripherally inserted central catheters in cancer patients using Caprini risk assessment model: a prospective cohort study

    There was no optimal risk assessment tool to stratify the risk of peripherally inserted central catheter-related venous thromboembolism (PICC-RVT) in cancer patients. We currently use the Caprini risk assessme...

    Yue Feng, Rujun Zheng, Yan Fu, Qiufen **ang, Zhiying Yue… in Supportive Care in Cancer (2021)

  5. No Access

    Article

    Status and influential factors of spiritual well-being in cancer patients with drug clinical trials: a cross-sectional study

    The purpose of this study was to investigate the spiritual well-being status of cancer patients in drug clinical trials and its influencing factors, and to provide theoretical support for the spiritual health ...

    Xue Hu, Jiaying Gao, Shiqi Liang, Zhiying Yue, Rujun Zheng in Supportive Care in Cancer (2023)

  6. No Access

    Article

    Social Media and Adolescent Mental Health

    This review delves into the intricate relationship between social media and adolescent mental health, scrutinizing underlying psychological mechanisms and proposing directions for future inquiry and interventi...

    Zhiying Yue, Michael Rich in Current Pediatrics Reports (2023)