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  1. No Access

    Article

    Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease

    The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in Alzheimer’s disease (AD) patients are unknown. Seventy-five partici...

    Jie Wang, Qi Huang, **ng Chen, Zhiwen You, Kun He, Qihao Guo in Molecular Psychiatry (2024)

  2. Article

    Open Access

    Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study

    Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the initial...

    Jie Wang, Yingfang He, **ng Chen, Lin Huang, Junpeng Li in Alzheimer's Research & Therapy (2024)

  3. No Access

    Article

    Comprehensive spatiotemporal map** of single-cell lineages in develo** mouse brain by CRISPR-based barcoding

    A fundamental interest in developmental neuroscience lies in the ability to map the complete single-cell lineages within the brain. To this end, we developed a CRISPR editing-based lineage-specific tracing (CR...

    Lianshun **e, Hengxin Liu, Zhiwen You, Luyue Wang, Yiwen Li, in Nature Methods (2023)

  4. No Access

    Article

    A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR

    Respiratory motion causes mismatches between PET images of the myocardium and the corresponding cardiac MR images in cardiac integrated PET/MR. The mismatch may affect the attenuation correction and the diagno...

    Zheng Zhang, **ng Chen, Qing Wan in European Journal of Nuclear Medicine and M… (2022)

  5. No Access

    Article

    Comparison of [68 Ga]Ga-FAPI-04 and [18F]-FDG for the detection of primary and metastatic lesions in patients with gastric cancer: a bicentric retrospective study

    The low sensitivity of [18F]-fluorodeoxyglucose ([18F]-FDG) for the diagnosis of gastric cancer limits its application. In this study, we aimed to investigate the potential advantage of [68 Ga]Ga-FAPI-04 over [18

    Donglang Jiang, **ng Chen, Zhiwen You in European Journal of Nuclear Medicine and M… (2022)

  6. No Access

    Article

    18F-FDG simultaneous PET/MR monitoring treatment response of a Turcot syndrome case

    Haiyan Wang, Qiaoyi Xue, Zhiwen You in European Journal of Nuclear Medicine and M… (2021)

  7. Article

    Open Access

    Standardized uptake values of 99mTc-MDP in normal vertebrae assessed using quantitative SPECT/CT for differentiation diagnosis of benign and malignant bone lesions

    Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large...

    Na Qi, Qingyuan Meng, Zhiwen You, Huiqian Chen, Yi Shou, Jun Zhao in BMC Medical Imaging (2021)

  8. Article

    Open Access

    Evaluation of SUVlean consistency in FDG and PSMA PET/MR with Dixon-, James-, and Janma-based lean body mass correction

    To systematically evaluate the consistency of various standardized uptake value (SUV) lean body mass (LBM) normalization methods in a clinical positron emission tomography/magnetic resonance imaging (PET/MR) s...

    Jun Zhao, Qiaoyi Xue, **ng Chen, Zhiwen You, Zhe Wang, Jianmin Yuan in EJNMMI Physics (2021)

  9. Article

    Open Access

    18F-FDG simultaneous PET/MR findings of a malignant transformation and metastases of abdominal wall endometriosis

    Haiyan Wang, Qiaoyi Xue, Yi Shou, **ng Chen in European Journal of Nuclear Medicine and M… (2020)

  10. No Access

    Article

    High-efficient adsorption and removal of elemental mercury from smelting flue gas by cobalt sulfide

    Nonferrous metal smelting produces a large amount of Hg0 in flue gas, which has caused serious damage to the environment and human health. In this work, amorphous cobalt sulfide was synthesized by a liquid-phase ...

    Hui Liu, Zhiwen You, Shu Yang, Cao Liu in Environmental Science and Pollution Resear… (2019)