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Article
Open AccessChromosome-scale genome assembly of medicinal plant Tinospora sagittata (Oliv.) Gagnep. from the Menispermaceae family
Tinospora sagittata (Oliv.) Gagnep. is an important medicinal tetraploid plant in the Menispermaceae family. Its tuber, Radix Tinosporae, used in traditional Chinese medicine, is rich in diterpenoids and benzylis...
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Article
Open AccessAn omics-based characterization of Wolfiporia cocos reveals three CYP450 members involved in the biosynthetic pathway of pachymic acid
Wolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with therapies. Nowadays, the unknown PA biosynthesis leads to difficulties i...
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Article
Open AccessComparative transcriptome analysis of root, stem, and leaf tissues of Entada phaseoloides reveals potential genes involved in triterpenoid saponin biosynthesis
Entada phaseoloides (L.) Merr. is an important traditional medicinal plant. The stem of Entada phaseoloides is popularly used as traditional medicine because of its significance in dispelling wind and dampness an...
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Article
Open AccessSensory TRP channels contribute differentially to skin inflammation and persistent itch
Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that b...
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Article
Open AccessPolyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
Paris polyphylla is an oriental folk medicine that has anticancer activities both in vivo and in vitro. Polyphyllin VII (PP7), a pennogenyl saponin from P. polyphylla has been found to...
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Article
Preparation and characterization of composite hydrogel beads based on sodium alginate
In this report, novel biopolymer hydrogels composed of sodium alginate (SA) and the oxidized sodium alginate (OSA) with an interpenetrating polymer network (IPN) structure were prepared by a combination of che...
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Article
pH-sensitive interpenetrating network hydrogels based on pachyman and its carboxymethylated derivatives for oral drug delivery
pH-sensitive, interpenetrating polymer network hydrogels were synthesized based on pachyman and its carboxymethylated derivatives (CMP) by the confunctional crosslinker agent epichlorohydrin. The structure an...
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Article
Sodium-glucose-linked transporter 2 inhibitors from Sophora flavescens
During the screening of a prefractionated natural product extract library (400 biota) against sodium-glucose-linked transporter 2 (SGLT2), a methanol fraction of the traditional Chinese medicine, Sophora flavesc...
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Article
Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples
Hexafluoroisopropanol (HFIP)-induced coacervation in aqueous mixed systems of catanionic surfactants of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS) was described in detail, and its...
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Article
Cytotoxic compounds from Laminaria japonica
Bioassay-guided purification of the EtOAc extract from a traditional Chinese medicine Laminaria japonica Aresch. yielded a new amine, 2,6-dibromo-4-(2-(methylamino)ethyl)phenol (1), along with 5 known compounds, ...
