96 Result(s)
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Zhigang **
Biomedicine
Oncology
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Article
Open AccessTherapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice
Signal transducer and activator of transcription 3 (STAT3) is usually constitutively activated in a variety of malignancies. Therefore, STAT3 may be a promising target for treatment of tumor cells. To explore ...
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Open AccessPoly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway
Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we inv...
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Open AccessDiagnostic utility of LunXmRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer
Progress in lung cancer is hampered by the lack of clinically useful diagnostic markers. The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnorma...
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Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis
Metastasis is a complicated process that depends largely on the interaction of primary tumors and the local host environment. In this study, we have established a new mouse model to mimic the process of tumor ...
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15-HETE suppresses K+ channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells
15-Hydroxyeicosatetraenoic acid (15-HETE) is an important hypoxic product from arachidonic acid (AA) in the wall of pulmonary vessels. Although its effects on pulmonary artery constriction are well known, it r...
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Open AccessPrevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers
The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and re...
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Open AccessUltrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice
The purpose of the study was to explore the anti-tumor effect of ultrasound -targeted microbubble destruction mediated herpes simplex virus thymidine kinase (HSV-TK) suicide gene system on mice hepatoma.
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Open AccessUltrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells
MDR1 gene encoding P-glycoprotein is an ATP-dependent drug efflux transporter and related to drug resistance of yolk sac carcinoma. Ultrasound microbubble-mediated delivery has been used as a novel and effecti...
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Open AccessAssociation between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis
X-ray repair cross-complementing group 1 (XRCC1) protein plays an important role in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of XRCC1 are suspected to have some relationship wi...
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Open AccessOCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma
OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well c...
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The Expression of Non-Mast Histamine in Tumor Associated Microvessels in Human Colorectal Cancers
Angiogenesis is essential for the growth, expansion and metastasis of human colorectal cancers (CRCs). Histamine produced by mast cells is a potent proangiogenic factor. However, the significance of non-mast c...
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Open AccessToxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT)
Patients treated for a thoracic malignancy carry a significant risk of develo** other lung lesions. Locoregional control of intrathoracic recurrences is challenging due to the impact of prior therapies on no...
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Open AccessConstraining the brachial plexus does not compromise regional control in oropharyngeal carcinoma
Accumulating evidence suggests that brachial plexopathy following head and neck cancer radiotherapy may be underreported and that this toxicity is associated with a dose–response. Our purpose was to determine ...
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Open AccessAssociation of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual ...
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Open AccessAssociation between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis
Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of ora...
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Open AccessExpression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 fo...
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Open AccessKi-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis
Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...
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Open AccessMatrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor
Matrine, a clinical drug in China, has been used to treat viral hepatitis, cardiac arrhythmia and skin inflammations. Matrine also exhibits chemotherapeutic potential through its ability to trigger cancer cell...
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Open AccessE2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation
E2F1 is the gatekeeper of the cell cycle controlling an analogous balance between proliferation and cell death. E2F1 expression is elevated in advanced prostate cancer. However, it is still unclear that the ro...
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Open AccessEvaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery
Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...
