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Article
Open AccessExpression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells
Interleukin-37 (IL-37) possesses the function of down-regulate systemic and local inflammation. It is unknown whether IL-37 is expressed in human regulatory T cells (Tregs) and its role in modulating the immun...
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Protocol
Pathophysiological Aspects of Sepsis: An Overview
Sepsis is defined as severe systemic inflammation in response to invading pathogens, or an uncontrolled hyperinflammatory response, as mediated by the release of various proinflammatory mediators. Although som...
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Article
Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function
The receptor of advanced glycation end products (RAGE) participates in a variety of pathophysiological processes and inflammatory responses. The aim of this study was to investigate the therapeutic potential o...
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Article
Open AccessSeptic encephalopathy: when cytokines interact with acetylcholine in the brain
Sepsis-associated encephalopathy (SAE) is a brain dysfunction that occurs secondary to infection in the body, characterized by alteration of consciousness, ranging from delirium to coma, seizure or focal neuro...
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Article
Open AccessTreatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury
Burn survivors develop long-term cognitive impairment with increased inflammation and apoptosis in the brain. Gelsolin, an actin-binding protein with cap** and severing activities, plays a crucial role in th...
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Article
Carbachol inhibits TNF-α-induced endothelial barrier dysfunction through alpha 7 nicotinic receptors
To test whether carbachol can influence endothelial barrier dysfunction induced by tumor necrosis factor (TNF)-α and whether the alpha 7 nicotinic receptor can mediate this process.
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Article
Open AccessAssociation between regulatory T cell activity and sepsis and outcome of severely burned patients: a prospective, observational study
To investigate the significance of changes in regulatory T cells (Tregs) activity and its relationship with sepsis, as well as outcome of patients with major burns.
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Article
Pathomorphological and quantitative bacteriological findings in various forms of primary surgery on gunshot wounds of extremities
It is well-known that ‘wound excision’ is essential in the primary treatment of wounds in war, particularly thorough debridement of the devitalized tissues around the path of a penetrating projectile. Nowaday...
