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Article
Open AccessImpacts of plasma microbial lipopolysaccharide translocation on B cell perturbations and anti-CD4 autoantibody production in people with HIV on suppressive antiretroviral therapy
. Up to 20% of people with HIV (PWH) who undergo virologically suppressed antiretroviral therapy (ART) fail to experience complete immune restoration. We recently reported that plasma anti-CD4 IgG (antiCD4IgG)...
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Article
Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder
Cocaine use is commonly associated with increased chronic systemic inflammation. However, the drivers for cocaine use-mediated systemic inflammation are not fully understood. In the current study, we recruited...
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Article
Open AccessProgesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells
Progesterone plays a protective role in preventing inflammation and preterm delivery during pregnancy. However, the mechanism involved is unknown. Microbial product translocation from a permeable mucosa is dem...
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Article
Open AccessSystemic translocation of Staphylococcus drives autoantibody production in HIV disease
Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.
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Article
Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder
Accumulating evidence suggests that genetic factors have a role in major depressive disorder (MDD). However, only limited MDD risk loci have been identified so far. Here we perform a meta-analysis (a total of ...
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Article
Open AccessDistinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection
Microbial signals have been linked to autoantibody induction. Recently, we found that purified anti-CD4 autoantibodies from the plasma of chronic HIV-1-infected patients under viral-suppressed antiretroviral t...
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Article
Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations
Greatly expanded brain volume is one of the most characteristic traits that distinguish humans from other primates. Recent studies have revealed genes responsible for the dramatically enlarged human brain size...
