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Article
Open AccessCircadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated by the circadian clock. However, the distinction between cir...
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Article
Open AccessHepatic Acat2 overexpression promotes systemic cholesterol metabolism and adipose lipid metabolism in mice
Acetyl coenzyme A acetyltransferase (ACAT), also known as acetoacetyl-CoA thiolase, catalyses the formation of acetoacetyl-CoA from acetyl-CoA and forms part of the isoprenoid biosynthesis pathway. Thus, ACAT ...
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Article
Open AccessHuman-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...
