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Article
Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA
Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. MicroRNAs (miRNAs), which function as post-transcriptional regulators, are utilized by human cytomegaloviru...
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Article
Human cytomegalovirus-encoded miR-US4-1 promotes cell apoptosis and benefits discharge of infectious virus particles by targeting QARS
Human cytomegalovirus (HCMV) can cause congenital diseases and opportunistic infections in immunocompromised individuals. Its functional proteins and microRNAs (miRNAs) facilitate efficie...
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Article
Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication
The interplay between the host and Human cytomegalovirus (HCMV) plays a pivotal role in the outcome of an infection. HCMV growth in endothelial and epithelial cells requires expression of viral proteins UL128, UL...
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Article
A cluster of 3′ coterminal transcripts from US12–US17 locus of human cytomegalovirus
Among all the human cytomegalovirus (HCMV) gene families, US12 family is relatively undefined in their transcriptional profile and biological functions. In this study, the transcription pattern and characteris...
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Article
Prevalence of microorganisms co-infections in human papillomaviruses infected women in Northern China
Due to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (HPV) infections, the present study aimed to evaluate microorganism co-infections and associ...
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Article
Open AccessDevelopment of a fluorescence–based multiplex genoty** method for simultaneous determination of human papillomavirus infections and viral loads
Persistent high-risk human papillomavirus (HPV) infection is correlated with an increased risk of develo** intraepithelial lesion or malignancy (NILM). The aims of the current study is to establish a method ...
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Article
Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells
Human cytomegalovirus (HCMV) encodes at least 26 microRNAs (miRNA). These miRNAs are utilized by HCMV to regulate its own genes as well as the genes of the host cell during infection. It has been reported tha...
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Article
Open AccessGenetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China
High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...
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Article
Down-regulation of human cytomegalovirus UL138, a novel latency-associated determinant, by hcmv-miR-UL36
MicroRNAs (miRNAs) are small RNAs, 19–23 nucleotides in length, which regulate a variety of cellular processes. Human cytomegalovirus (HCMV) encodes only one intronic miRNA: human cytomegalovirus microRNA UL36...
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Article
Overlap** transcription structure of human cytomegalovirus UL140 and UL141 genes
Transcription of human cytomegalovirus UL/b′ region has been studied extensively for some genes. In this study, transcripts of the UL140 and UL141, two of the UL/b′ genes, were identified in late RNAs of three...
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Article
Open AccessAnalysis and map** of a 3′ coterminal transcription unit derived from human cytomegalovirus open reading frames UL30–UL32
It has been predicted that the UL31 gene originates from the positive strand of the human cytomegalovirus (HCMV) genome, whereas the UL30 and UL32 genes originate from the complementary strand. Except for the ...
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Article
Open AccessThe expression of interleukin-32 is activated by human cytomegalovirus infection and down regulated by hcmv-miR-UL112-1
Interleukin-32 (IL-32) is an important factor in innate and adaptive immune responses, which activates the p38MAPK, NF-kappa B and AP-1 signaling pathways. Recent reports have highlighted that IL-32 is regulat...
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Article
Transcription characteristics of the human cytomegalovirus UL13 gene
The human cytomegalovirus (HCMV) UL13 gene is located in the unique long (UL) region of its genome. The transcript structure of UL13 gene has not been investigated to date. By using cDNA library screening, nor...
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Article
Human cytomegalovirus RL13 gene transcripts in a clinical strain
Human cytomegalovirus (HCMV) RL13 gene is a member of the RL11 gene family. To study the expression kinetics and transcript structures of the gene, screening of cDNA library, Northern blot, 3′ and 5′ RACE anal...
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Article
Open AccessAn antisense transcript in the human cytomegalovirus UL87 gene region
Rapid advances in research on antisense transcripts are gradually changing our comprehension of genomic and gene expression aspects of the Herpesviridae. One such herpesvirus is the human cytomegalovirus (HCMV). ...
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Article
Open AccessCharacterization of the transcripts of human cytomegalovirus UL144
The genome of human cytomegalovirus (HCMV) has been studied extensively, particularly in the UL/b' region. In this study, transcripts of one of the UL/b' genes, UL144, were identified in 3 HCMV isolates obtain...
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Article
Open AccessA rapid method to screen putative mRNA targets of any known microRNA
microRNAs (miRNAs) are a group of regulatory RNAs that regulate gene expression by binding to specific sequences on target mRNAs. However, functional identification of mRNA targets is usually difficult and tim...
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Article
Transcription pattern of UL131A-128 mRNA in clinical strains of human cytomegalovirus
Human cytomegalovirus (HCMV) mRNA was obtained from human embryonic lung fibroblast cells infected by HCMV clinical strains from urine samples of infants at different kinetic periods. The cDNA of UL131A-128 mRNAs...
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Article
Diagnostic value of HCMV pp65 antigen detection by FCA for symptomatic and asymptomatic infection: compared to quantification of HCMV DNA and detection of IgM antibody in infants
Human cytomegalovirus (HCMV) can cause symptomatic or asymptomatic infection in infants. One hundred and twenty-six infants were assessed clinically for disease in infantile period. Eighty of them were classif...
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Article
Human cytomegalovirus UL145 gene is highly conserved among clinical strains
Human cytomegalovirus (HCMV), a ubiquitous human pathogen, is the leading cause of birth defects in newborns. A region (referred to as UL/b′) present in the Toledo strain of HCMV and low-passage clinical isola...
