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4,193 Result(s)
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The **gaze ophiolite (Tibet): a peculiar oceanic lithosphere
The **gaze ophiolite which outcrops along the Yarlung Zangbo river, southern Tibet, locally displays a complete ophiolitic sequence from marine sedimentary cover over basaltic volcanics to the north, to fresh ...
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Abundance variation of iridium and trace elements at the Permian/Triassic boundary at Shangsi in China
Despite recent searches for anomalous iridium(Ir) concentrations at the Permian/Triassic boundary (P/Tr) of marine sediments1–3, no Ir above a level of 0.5 p.p.b. (parts per 109) has been found. Detailed event–st...
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Efficient photovoltaic devices for InP semiconductor/liqud junctions
AN alternative to conventional solid-state photovoltaic devices is the semiconductor/liquid junction. Liquid-junction cells not only offer the possibility of integrating energy conversion and storage functions1, ...
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Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes
THE products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes1–4. The non-polymorph...
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Binding of chaperonins
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T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol
THE murine t-complex encodes t-complex polypeptide-1 (TCP1)1, which is constitutively expressed in almost all cells, and upregulated during spermatogenesis2,3. Mammalian sequences have >96% identity with each oth...
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A plate-tectonic speed limit?
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Protective effects of oligosaccharides in P-selectin-dependent lung injury
NEUTROPHIL recruitment into tissues is a multistep process involving sequential engagement of adhesion molecules, including selectins (E,P,L), which are reactive with oligosaccharides, and the family of (β2 in...
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Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77
ENGAGEMENT of the T-cell antigen receptor (TCR) on immature thymic T cells induces death by apoptosis1–3. Although several lines of evidence indicate that apoptosis requires de novo gene expression, little is kno...
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Turning of nerve growth cones induced by neurotransmitters
PATHFINDING by growing nerve processes in the develo** nervous system depends on the turning response of the growing tip, the growth cone, to extracellular guidance cues1–4. There is evidence in vivo and in cel...
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Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs
IMMUNE responses are orchestrated by CD4 T lymphocytes, which receive a cognitive signal when clonally distributed receptors are occupied by major histocompatibility complex (MHC) class II-bound peptides on a...
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Nucleation of microtubule assembly by a γ-tubulin-containing ring complex
The highly conserved protein γ-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified γtubulin complex from Xenopus consisting of at least seven diffe...
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Three distinct signalling responses by murine fibroblasts to genotoxic stress
GENOTOXIC stress triggers signalling pathways that mediate either the protection or killing of affected cells. Whereas induction of p53 involves events in the cell nucleus1, the activation of transcription factor...
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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
PROGRAMMED cell death (apoptosis) is a prominent feature of the development of the immune and nervous systems1,2. The identification of the Caenorhabditis elegans cell death gene, ced-3, as a prototype of the int...
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Polymer gels with engineered environmentally responsive surface patterns
The polymer gels called hydrogels may be induced to swell or shrink (taking up or expelling water between the crosslinked polymer chains) in response to a variety of environmental stimuli, such as changes in p...
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Ultradry seed storage cuts cost of gene bank
Today we are faced with an urgent challenge to organize the efficient conservation of biodiversity. In the case of plants, one way of doing this is to store their seeds in a gene bank. The effective preservati...
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Dilemma over genetics and population in China
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Turning of nerve growth cones induced by localized increases in intracellular calcium ions
Guidance of develo** axons involves turning of the motile tip, the growth cone, in response to a variety of extracellular cues1,2. Little is known about the intracellular mechanism by which the directional sign...
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Phase transitions in the incoherent lattice fluctuations in YBa 2Cu3O7-δ
The growing body of experimental evidence1,2,3,4,5,6,7 for the existence of complex textures of charges and spins in the high-temperature superconductors has drawn attention to the so-called ‘stripe-phase’ model8
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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
BRCA1 encodes a familial breast cancer suppressor that has a critical role in cellular responses to DNA damage1,2. Mouse cells deficient for Brca1 show genetic instability, defective G2–M checkpoint control and r...