2,545 Result(s)
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Zheng-**ong **
Internal Medicine
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Article
The role of cryosurgery in the treatment of hepatic cancer: a report of 113 cases
From November 1973 to June 1992, cryosurgery with liquid nitrogen (−196°C) was performed on 113 patients with hepatic cancer, including 107 patients with primary liver cancer (PLC) and 6 patients with secondar...
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Somatic diversification of antibody responses
During the last decade, a substantial body of knowledge has been obtained on the generation of somatic diversification of the B cell repertoire, especially with regard to differentiation and selection of B cel...
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Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:PolyC12U in the treatment of HIV infection
In this multicenter, randomized, double-blind study the activity of polyI:polyC12U administered with zidovudine was evaluated in the treatment of HIV infection. Thirty-six HIV-positive, pre-AIDS individuals (100–...
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Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA-in vitro and in vivo studies
Recent findings suggest that over-expression of activated H-ras inhibited apoptotic cell death by blocking the activity of apoptotic endonuclease(s). This study was designed using antisense H-ras oligodeoxynucleo...
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Weight variability and incident disease in older women: the Iowa Women's Health Study
OBJECTIVE: To evaluate the association between weight variability and disease incidence in women. DESIGN: Prospective cohort study, following women from 1986 through 1992. METHODS: A population-based sample of...
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Chylous ascites
A 43-yr-old female underwent a normal endoscopic retrograde cholangiopancreatography (ERCP) because of ill-defined abdominal discomfort. A life-threatening pancreatitis with massive peripancreatic necrosis ens...
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Primary study of neovasculature correlating with metastatic nasopharyngeal carcinoma using computer image analysis
The significance of neoangiogenesis in the metastasis of nasopharyngeal carcinoma (NPC) was investigated to clarify the role neovascularity in the prognosis of NPC and the probability of antiangiogenesis prev...
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Mechanisms of cell death in hypoxia/reoxygenation injury
Investigation of death pathways during cell injury in vivo caused by ischemia and reperfusion is of clinical importance, but technically difficult. Heterogeneity of cell types, differences between organ systems, ...
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Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury
We investigated mechanisms of cell death during hypoxia/reoxygenation of cultured kidney cells. During glucose-free hypoxia, cell ATP levels declined steeply resulting in the translocation of Bax from cytosol ...
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Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25
Multiple distinct regions of chromosome 6 are frequently affected by losses of heterozygosity in primary human ovarian carcinomas. We introduced a normal human chromosome 6 into HEY and SKOV-3 ovarian carcinom...
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35th Annual Meeting of the European Association for the Study of Diabetes
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Human herpesvirus 8 (KSHV) contamination of peripheral blood and autograft products from multiple myeloma patients
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), has recently been identified within the bone marrow dendritic cells of multiple myeloma (MM) patients. This virus cont...
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Generation of dendritic cells from peripheral blood of patients at different stages of chronic myeloid leukemia
We report a method to generate dendritic cells (DC) from frozen leukapheresis products of patients with chronic myeloid leukemia (CML), using sterile culture bags and serum-free culture medium, ie conditions f...
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Lessons learned from BRCA1 and BRCA2
BRCA1 and BRCA2 are breast cancer susceptibility genes. Mutations within BRCA1 and BRCA1 are responsible for most familial breast cancer cases. Targeted deletion of Brca1 or Brca2 in mice has revealed an essen...
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Preoperative high-dose chemotherapy with peripheral blood stem cell support as a primary management of locally advanced breast cancer
Locally advanced breast cancer (LABC) has a poor prognosis with a high risk of local recurrence and distant metastasis. Preoperative combined chemotherapy with or without granulocyte colony-stimulating factor ...
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Peripheral blood progenitor cell mobilisation alters myeloid, but not erythroid, progenitor cell self-renewal kinetics
Transplantation of progenitor cells which have been mobilised into the bloodstream (PBPC) following the administration of G-CSF results in more rapid neutrophil recovery than transplantation of bone marrow (BM...
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MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2 T
The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that ...
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Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor
OBJECTIVE: Based on the inhibitory effects of teasaponin on pancreatic lipase activity in vitro, this study was performed to clarify whether teasaponin prevented obesity induced in mice by a high-fat diet for 11 ...
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Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma
To gain new insight into the molecular mechanism underlying the pathogenesis of human primary hepatocellular carcinoma (HCC), we searched for HCC-specific molecules through screening genes that are differentia...
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New designs for cancer vaccine and artificial veto cells
Antigen-presenting cells (APC) can be refaced with “protein paints” that change the appearance of their T cell-oriented trans signal arrays. Our group has developed three categories of protein paints suitable for...
